Alison Cooper

Alison Cooper

Alison Cooper is a senior lecturer at the University of Birmingham, where she teaches neuroscience and pharmacology.

Location University of Birmingham

Activity

  • Yes, that's right. there are many examples, but one which has a big impact on prescribing in many parts of the world relates to mediation used to lower blood pressure. For reasons that are not well understood, those with African/Caribbean ancestry tend to respond differently to those of caucasian ancestry.

  • This activity has particular relevance in the current pandemic. Recent data has suggested that the drug dexamethasone has a positive impact on the most ill patients. This drug has been used for decades, is off patent and therefore very cheap. You may want to consider the implications of this finding as compared to identifying and testing a new drug.

  • The financial aspects of drug development are complex and, inevitably where money is involved it seems, can reveal the unpleasant side to business activity

  • There is evidence that the interaction of the drug and receptor can result in change to the receptor - something called induced fit. However, undesirable side effects relating to medicinal drug action are most commonly due to the drug interacting with receptors on cells/parts of the body where the drug action is not needed or where the drug has too great an...

  • ask away

  • And here is the core point Ian - there isn't one single accepted definition so a description of what we mean by drug is important when communicating with others.

  • A good set of diverse drugs with diverse purposes!

  • That's right - it depends on whether we are thinking of "drug" specifically to mean drugs that humans might take recreationally and potentially abuse or whether we consider the definition to extend to include medicinal substances.

  • A good point Rachel. However, psychological effects are underpinned by changes in the way the neurons of the brain function and these are physiological effects.

  • The meaning of words can show differences according to the culture in which they are used. We have a diverse range of participants on the course so you may find that your definition varies from those given by others

  • This is a good point. The term "drug" can be applied both to a medicine but also a substance that might be abused and that causes harm such as heroin.

  • Yes, that's right. Many potential drugs start down the path to full development and use in humans but many fail at the various hurdles so the cost of these failures has to be recouped via drugs that do make it all the way to be prescribed.

  • Hello all,
    I see that some of you are already busily working your way through the course materials. I'll drop in and keep an eye on your comments when I can but do remember that your fellow learners are a great source of support and information too.

  • @CatherinePolidano
    Interesting questions!
    1. there are many groups of dopamine=producing neurones in the brain. See here for a diagram:
    https://commons.wikimedia.org/wiki/File:Dopaminergic_pathways.svgThe ones that are most closely linked with PD are those that form the nigrostriatal pathway. The ones most closely associated with daopmine release during...

  • Thanks for sharing your father's experience - it helps illustrate the point that symptoms are diverse and different people have different sets of symptoms. A subset of people do not have tremor and the reason for this remains unclear. However, tremor is generally the symptom that L-dopa is least good at treating, which matches your father's expereince.

  • Dear Gaurav,
    I'm not sure what you mean by neuron production - there are no new neurones produced in this area of the adult brain as far as we know. This is unfortunate as the ability to produce new neurons here might help counteract any neurodegeneration.
    The other structures are there purely for orientation for anyone wanting to look into the anatomy of...

  • Dear Catherine, this "slice" is an accurate representation of the brain so hasn't had to be squashed to make a 2D picture. If yuo want to see where the midbrain is, try here:
    https://www.brainfacts.org/3d-brain#intro=true&focus=Brain-brain_stem-midbrain

  • Dear Gaurav, I'm sorry if the course did not meet your expectations. I am glad that it stimulated you to research for yourself, building on the platform I provide - that was my intended model as different people want different outcomes for the course and also different people prefer different modalities for learning. Unfortunately many activities cannot be...

  • Thanks for your comment. I set out to design the course that way as participants are diverse in knowledge and interest so I am really pleased to hear that this has worked for you.

  • I can only agree - your brain is a dynamic system it is changing at the microscopic scale throughout life and in response to your expereinces. So, the more you use it the more connections between neurons you have.

  • Thanks for sharing your experience - what this illustrates is that what works for one person might not work for another and that a degree of trial and error might be needed to get medications right - a valuable piece of knowledge for anyone who might be in the middle of changing their medication

  • This made me smile! Yes, the more we find out about the brain, the more we realise we don't know....!

  • Some great sources here - the involvement of the ENS is a major focus of research

  • @IanCampbell for psychosis the evidence suggests it is more likely due to the action of the drug treatments than part of the pathology. See some evidence for that here:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137166/

  • You are correct that PD seems to be associated with changes in mental health too and these seem to be more than reactive to a change in health since, for example, the prevalence of depression in those with PD is greater than it is in those with arthritis

  • Perhaps a surprise - but Drosophila, the tiny flies used in a lot of genetic research, share many of the proteins involved in neural activity with humans so they make good models for trying to understand basic processes. There's more on this here:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900015/

  • An excellent summary. Your statement that drugs don't slow the development but are aimed at reducing the impact of the symptoms is an important point. Consequently there is a lot of work trying to find something that will stop the progression or even prevent neurodegeneration in the first place.

  • @finnfinn We will look at the genetic versus non-genetic elements in the course. For some people there is a clear genetic link and, as you say Finn, this is most closely associated with a younger onset. However, for many people there isn't a link and you may hear the term "idiopathic" to describe their situation. This is just a technical word for "unknown...

  • the non-motor features are covered in week 3 activities - hopefully you'll get your questions answered!

  • can you explain how you came to this conclusion?

  • Hello everyone!
    I see many of you are already busily posting your thoughts and, in particular, it is really helpful for al participants to hear others impressions both of PD but also the course. It is challenging to put a course together for an audience you don't know - you will have such varied knowledge and interests but I hope you can all find something...

  • Pretty good summary Mike. The important bit here is that we are realizing that it is not just dopamine in one pathway that seems to be changed in PD. This has the potential to mean that some of the currently less-well covered symptoms might be treatable with additional drugs or other interventions.

  • Hi Marion - please do ask if there are particular points that you need guidance with. Also, I run a "basics of the brain" MOOC through Futurelearn and you might find that the core concepts we cover there are helpful to you.

  • Hello everyone - good to see so many of you here and busy already! I can also see that we have people with various experiences of PD joining - this real experience is so very valuable in helping the participants get the most out of this course, so thank you for being so open and sharing your own experiences. I will be dropping in and taking a look at your...

  • Not far off. The way that the electrical signals (action potentials) are generated and propagated down the axon relies on the movement of ions in and out of the axon. There is some leakage along the axon which means that, without myelination, the electrical signal would slowly decay the further away from the site of initial generation (at the cell body) you...

  • Some of you have mentioned the periaqueductal grey - this is a region found in the midbrain part of the brainstem which is the evolutionarily older parts of the brain. It seems to be involved in a lot of functions including basic survival processes, how individuals respond to different forms of threat, modulating pain responses, and a variety of other...

  • There is evidence that bringing information together at one point in time helps to encode it in the brain and that retrieving that information is easier when those conditions are reproduced. Perhaps the reason why smelling a particular perfume instantly reminds you of a particular person. We can see some evidence for how this might work at the level of...

  • I like your description that the brain is "a web of connections". Interestingly many of the recently built supercomputers are being built with this kind of connectivity rather than more traditional arrangements that are still found in domestic computers. For example, see this one:
    http://apt.cs.manchester.ac.uk/projects/SpiNNaker/

  • and then continue that process through "the next cell"

  • Lots of interesting points being made here - as you are identifying there is no simple answer. if it is only about detecting sensory information, would that mean that the thermostat on your cooker is conscious?!

  • Alison Cooper replied to [Learner left FutureLearn]

    You are all right to some extent. Many drugs act as keys to the lock (receptor) and this either mimics the action of the normal key or prevents the normal key from working - these are scientifically named agonists and antagonists respectively. However, there is some evidence that drugs can act to modify the normal working of the natural agonist, so you are not...

  • If you are wondering what the myelin looks like, the image below is of a peripheral neuron that has a myelin sheath wrapped around it. In the periphery this job is done by glia known as schwann cells, in the brian the job is done by oligodendrocytes
    https://en.wikipedia.org/wiki/Myelin#/media/File:Myelinated_neuron.jpg

  • Yes - the key point being that opioids are involved in many different aspects of brain function - sometimes we can use this to advantage, eg for pain relief, but these systems can be hijacked if someone is abusing drugs and can cause harm. A bit of a goldilocks principle - you need just the right amount of opioid neurotransmission, not too much, not too little