Skip to 0 minutes and 9 secondsWelcome to this course in bacterial comparative genomics. My name is Dr. Ulrike Boehme. And I'm Dr. Christine Boinett. Comparative genomics is used to compare genomic features between different or similar organisms. In this course, we'll be using a freely available software, known as the Artemis Comparison Tool, to compare bacterial genomes. There will be plenty of articles, screencasts and interviews to guide you through the process. You'll also have the opportunity to join in constructive discussions with other learners and share your findings. These discussions will be especially useful in week three, where you'll need to tackle a real research problem. Join us in this new adventure, where we delve further into bacterial genomes.
Duration 3 weeks
Weekly study 5 hours
Digital upgrade Free
Gain experience in using the Artemis Comparison Tool for comparative genomics
Disease outbreaks are still a big problem in our modern world. Comparison between two or more bacterial genomes can help improve understanding of the causes of pathogenicity and outbreaks of disease caused by bacteria.
On this course you will learn how to use the free Artemis Comparison Tool (ACT). Developed at the Wellcome Sanger Institute, ACT will help you to visualise the comparison of genomes and analyse the results.
What topics will you cover?
* Introduction to comparative genomics
* Introduction to ACT
* Analyse available data
* Generate your own comparison files
* Make your own comparisons in ACT
* Identify pseudogenes in Mycobacterium leprae using ACT
* Peer review project: Comparative genomics on two clinically relevant plasmids from Shigella
When would you like to start?
Most FutureLearn courses run multiple times. Every run of a course has a set start date but you can join it and work through it after it starts. Find out more
Who is the course for?
This course would benefit those interested in learning how to use tools to investigate and research bacterial genomes, and acquire bioinformatics skills to evaluate the role of microbial genes in disease. Learners will gain experience in comparative genomics, using the Artemis Comparison Tool to probe, visualise and compare genomes, and analyse the results.
This course will be of interest to anyone interested in microbiology, including undergraduates, post-graduates, biomedical researchers, microbiologists, bioinformaticians, teachers, and healthcare professionals.
The opportunity to gain experience in using the Artemis Comparison Tool, a computational tool designed for comparative genomics, will also be of interest to all those who have studied our pre-requisite courses: those with an interest in genomics and disease outbreaks, teachers and their 16-18-year-old science and computing students.
Ideally, you will have completed Bacterial Genomes: From DNA to Protein Function Using Bioinformatics and Bacterial Genomes: Accessing and Analysing Microbial Genome Data before joining the course.
Who will you learn with?
Wellcome Genome Campus Advanced Courses and Scientific Conferences are offering everyone who joins this course a free digital upgrade, so that you can experience the full benefits of studying online for free. This means that you get:
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