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Pharmacokinetics: Drug Dosing in Renal Disease
Learn how renal disease affects kidney function and how to apply dosing regimens
On this course, you will learn the principles of pharmacokinetics and drug dose adjustment in patients with renal disease. You will be introduced to basic kidney physiology and functions, including the filtration, secretion and reabsorption of water, and the mechanisms of renal drug excretion.
You will learn how to calculate renal clearance, and how to recommend dosing regimen for patients with the disease. You will also explore the general principles for dosage adjustment in dialysis patients, and be able to describe the typical clinical presentation of chronic renal failure.
In this course, you will learn the principles of pharmacokinetics and drug dose adjustment in renal disease.
Week 1 - Renal Physiology and Function
Learn the basic physiology of the kidneys and describe filtration, secretion and reabsorption of water, electrolytes and small molecular weight non-electrolytes
Week 2 - Pharmacokinetics and Dosing Regimen in Renal Failure
Understand the mechanisms of renal drug excretion
Week 3 - Dosing Regimen And Therapeutic Drug Monitoring in Renal Failure
Become proficient at interpolating or extrapolating concentration based on first order kinetics
Week 4 - Dosing Regimen in Renal Dialysis
Learn to calculate dialysis clearance using the A-V difference method/ using dialysate concentration
Week 5 - Acute Renal Failure
Explore pathophysiology and the most common causes of prerenal, intrinsic, and postrenal
Week 6 - Chronic Renal Failure
Learn to describe the typical clinical presentation of chronic renal failure
What will you achieve?
By the end of the course, you‘ll be able to...
- Explain basic physiology of the kidneys
- Calculate renal clearance by excretion rate method / renal clearance by urinary recovery method
- Describe pharmacokinetic factors that affect dialysability of drugs
- Describe the most common causes of chronic renal failure
- Assess an appropriate therapy for chronic renal failure and secondary complications
Who is the course for?
This course is for anyone requiring clinical pharmacokinetic knowledge, including undergraduate pharmacy students, post-graduate pharmacy students and pharmacists in clinical practice.
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