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Exploring the Landscape of Antibiotic Resistance in Microbiomes

Explore the exciting microbial world and how this knowledge is revolutionising our understanding of antibiotic resistance.

Exploring the Landscape of Antibiotic Resistance in Microbiomes

Find out why and how to perform large scale studies on antibiotic resistance

In the fight against antibiotic resistance, microbial communities and the resistomes they carry are increasingly important data sources. This field is rapidly advancing, but the big data generated is creating a gap between health sciences and bioinformatics.

On this three-week course from the University of Oslo, you’ll begin to close this gap. With the help of a team of experts, you’ll explore why and how to study resistomes, including hands-on resistome analysis.

Discover how antibiotic resistance has become one of the most urgent health threats

The misuse and overuse of antibiotics has accelerated the development and spread of antibiotic resistance, making antibiotics ineffective.

You’ll start by looking at how studies are contributing to the current understanding of drug resistance. Through this examination, you’ll discover the relation between antibiotic use, its lack of target specificity, the void in discovery of new antibiotics, and the current drug resistance crisis.

Examine how the study of antibiotic resistance genes helps us understand antimicrobial resistance

Microbes develop antibiotic resistance by using instructions from their genes, and there can often be a variety within a microbial community.

This course will guide you through the study of resistomes, exploring the different resistance mechanisms, how drug resistance genes are exchanged among bacteria, how studies are designed, how to handle samples, and how to analyse the data.

Embark on a journey of real exploration of resistome data using ResistoXplorer

Through hands-on exercises and analysis, you’ll be introduced to a real experience of resistome analysis. You’ll use ResistoXplorer, a web-based resource developed at the University of Oslo that doesn’t require advanced bioinformatics skills.

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Skip to 0 minutes and 2 seconds Invisible to the naked eye, microbes are everywhere. And so are the antimicrobial resistance genes they carry. These have increased in abundance and types due to overuse. Antibiotic resistance now one of our largest health threats. To slow down the problem actions to reduce antibiotic use are being implemented worldwide. An important data source is microbial communities and the resistance genes they care, the resistome. They help us to answer questions such as how drug resistance acquired and how it is transmitted. This field is rapidly advancing thanks to new sequence technologies and analytical tools. It’s revolutionising the way we understand antimicrobial resistance. But there is a challenge.

Skip to 1 minute and 3 seconds The large data generated from such communities is creating a growing gap between health science disciplines and bioinformatics. This threatens the speed that research needs to address the current crisis. This course aims to help closing this gap. We often find ourselves wondering– We bring together experienced clinicians. But first, I have to kill a myth. Public health experts. - And boy, is this a story to be shared Molecular microbiologists and bioformations to explore with you why we want and how we can study resistance in microbial communities. You will experience an exciting and mystifying course, including hands-on exploration of real resistome data. Join us in this fascinating journey.

What topics will you cover?

  • The antibiotic resistance crisis
  • Why are microbial communities and the antibiotic resistance genes they carry-the resistome-relevant for the understanding of drug resistance?
  • The off-target impact of antibiotics on microbial communities
  • How are resistome studies designed and conducted?
  • Insights on how to explore resistome data, including a hands-on experience on how to use ResistoXplorer for visual, statistical and functional analysis of resistome data.

When would you like to start?

Start straight away and learn at your own pace. If the course hasn’t started yet you’ll see the future date listed below.

Learning on this course

You can take this self-guided course and learn at your own pace. On every step of the course you can meet other learners, share your ideas and join in with active discussions in the comments.

What will you achieve?

By the end of the course, you‘ll be able to...

  • Reflect upon the urgency in addressing the antimicrobial resistance crisis
  • Demonstrate knowledge on why microbial communities and the antibiotic resistance genes they carry-the resistome-are relevant for the understanding of drug resistance
  • Discuss the consequences of the off-target impact of antibiotics on microbial communities
  • Demonstrate knowledge on how resistome studies are designed and conducted
  • Apply the acquired knowldedge in a hands-on activity that uses ResistoXplorer for visual, statistical and functional analysis of resistome data

Who is the course for?

This course will be particularly useful for clinicians, basic research students, and scientists in health-science fields, as well as public health professionals. You may also find it appealing if you work in the field of bioinformatics, with a special interest in strengthening multi-disciplinary collaborations.

What software or tools do you need?

You will be invited for a hands-on experience using ResistoXplorer, a free web tool developed at the University of Oslo. The tool works with major modern browsers such as Google Chrome, Mozilla Firefox, Safari, and Microsoft Internet Explorer.

Who will you learn with?

I am Fernanda Petersen, a Professor at the University of Oslo in Norway. My group brings together scientists from various fields, to address challenges related to infections and antibiotic resistance.

I am an Associate Professor at the University of Oslo and my interests span from understanding the molecular interactions between microbes to exploring strategies to fight antibiotic resistance.

I am a bioinformatician pursuing my Ph.D. at the University of Oslo, Norway. My research interest involves analyzing and visualizing big Omics data such as metagenomics.

I am Gabriela Salvadori, a postdoc researcher at the University of Oslo.
My main interests are the study of human resistome and state-of-the-art methods to hunt for new antibiotic resistance genes.

Who developed the course?

University of Oslo

Founded in 1811, the University of Oslo (UiO) is the highest ranked institution of education and research in Norway.

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Unlimited

$15.83/month

Billed at $189.99 for a year

Endless possibilities!

  • Access to this course
  • Access to ALL eligible short courses with additional benefits, for a year
  • Discuss your learning in comments
  • Digital certificate when you're eligible

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*FutureLearn considers a short course complete when a learner has engaged with 90% of the content. For enrolments to short courses with the possibility of Upgrade in the year of 2020, enrolments with an Upgrade are completed 5.31 times as often as enrolments with basic access

*FutureLearn considers a short course complete when a learner has engaged with 90% of the content. For enrolments to short courses with the possibility of Upgrade in the year of 2020, enrolments with an Upgrade are completed 5.31 times as often as enrolments with basic access

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