Fernanda Petersen
I am Fernanda Petersen, a Professor at the University of Oslo in Norway. My group brings together scientists from various fields, to address challenges related to infections and antibiotic resistance.
Location Norway
Activity
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@LúciaTengan Glad to see students from Dentistry participating in the course.
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Welcome!
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Totally agree. Microbiome studies in general focus mostly on high income countries. Here an interesting comment on the skewed data we have on microbiomes: https://www.science.org/content/article/studies-human-microbiome-ignored-developing-world-potentially-compromising-treatments. "Studies of human microbiome have ignored the developing world, potentially...
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Hi Lucia, I hope you will enjoy the course :-)
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Thanks, Alison. Yes, we see a translation problem here and are checking how to fix it.
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Welcome to the course! We hope you will enjoy it!
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Fernanda Petersen replied to Jude Aweya
I hope you will like it!
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Fernanda Petersen replied to Alma Lopez Garcia
I hope you will enjoy it!
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You have a good point. Regulations on prescription are important, but not without challenges. There is a market out there that is difficult to control. Spreading awareness is important.
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Agree, this is a large problem. Adding to this, we have regions around the world with poor or no access even to medical care.
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Hello, Alma! I hope you will enjoy the course!
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Fernanda Petersen replied to Yadiris Cotilla
Welcome, Yadiris!
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Fernanda Petersen replied to [Learner left FutureLearn]
Welcome! I hope you will enjoy the course
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Welcome, Gold! Hope you will enjoy the course :-)
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Fernanda Petersen replied to [Learner left FutureLearn]
Hello :-)
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Hi Achando! Here it is important to mention that we still need more research-based evidence to help clinicians in taking decisions on best prescription practices for different conditions. For tuberculosis, for instance, compliance is not easy, but it is key. Here is an interesting article comparing 6 and 9 months regimens: USPHS Tuberculosis Short-Course...
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Welcome to the course! Hope you will enjoy it :-)
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This is an interesting point. Although the relevance of disinfectants for resistance is disputed based on the modest reductions in susceptibility in settings of frequent use, there is a need for more studies in the field.
Here is an interesting discussion on this issue: Resisting disinfectants https://doi.org/10.1038/s43856-021-00070-8
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Good luck!
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Here are 2 useful links, if you are after Web-tools to help calculating sample size in microbiome research:
1.Kelly BJ, Gross R, Bittinger K, Sherrill-Mix S, Lewis JD, Collman RG, et al. Power and sample-size estimation for microbiome studies using pairwise distances and PERMANOVA. Bioinformatics. 2015;31(15):2461–2468. [PMC free article]
2. Mattiello F,... -
It is challenging to perform a formal sample size evaluation for most resistome studies: (1) there is still a paucity of studies in the field, and (2) the variation among individuals in defined populations are largely unknown.
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Fernanda Petersen made a comment
Saliva has usually >90% human DNA and the remaining is microbial DNA. Depleting human DNA is therefore a good strategy if you are focusing on the microbiome.
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Good luck! Looking forward to seeing it!
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@oluchiOkonkwo Drug resistant infections would not be caused by a single infection agent, which would be a different challenge. Perhaps more important is that AMR shakes the very foundations of modern medicine :-)
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Have you published your work already? If yes, please post the link to it :-)
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You may enjoy reading this one: https://www.nature.com/articles/s41467-019-08853-3 "Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach...
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I really enjoy this article. The authors did not go as far as measuring the risk of infections by drug resistant microorganisms later in life, but this is really an awake. I hope to see soon more research in this field. Thanks for sharing your thoughts :-)
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Hi George,
glad to hear you enjoyed it.
1.Clemente JC, Pehrsson EC, Blaser MJ, et al. The microbiome of uncontacted Amerindians. Sci Adv. 2015;1(3):e1500183. doi:10.1126/sciadv.1500183
2.D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD. Antibiotic resistance is ancient.... -
Glad to meet you all! Hope you will enjoy the course :-)
