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Online course

Genomic Technologies in Clinical Diagnostics: Molecular Techniques

Learn how molecular genetic techniques are used to identify the genetic factors that contribute to the development of disease.

Free:

  • Access to the course for its duration + 14 days, regardless of when you join (this includes access to articles, videos, peer review steps, quizzes)
  • No certificate

Upgraded:

  • Unlimited access to the course, for as long as it exists on FutureLearn (this includes access to articles, videos, peer review steps, quizzes)
  • A Certificate of Achievement when you complete the course

Find out more

Genomic Technologies in Clinical Diagnostics: Molecular Techniques

This course is part of the Genomics in Healthcare program, which will enable you to study genomics at postgraduate level, for CPD or as a gateway to further study.

Why join the course?

Powerful new technologies have been driving forward immense and exciting changes in clinical practice.

The days of peering down the microscope to detect chromosome abnormalities are gone, replaced by chromosome analysis at the genomic level. Invasive Down syndrome tests in pregnancy have made way for the evaluation of fetal DNA in maternal blood. And instead of laborious gene-by-gene targeted sequencing, we can now sequence all of our genes in parallel in a single experiment.

Understand and apply molecular genetic techniques

This postgraduate-level course, in combination with Genomic Technologies in Clinical Diagnostics: Next Generation Sequencing Technologies, will help you understand these new and established genetic technologies, and their application to clinical practice.

This course focuses on molecular techniques. By the end, you will be able to demonstrate knowledge and applicability of the molecular principles behind:

  • array comparative genomic hybridisation (array CGH);
  • karyotyping;
  • fluorescent in situ hybridisation (FISH);
  • Southern blotting;
  • multiplex ligation probe amplification (MLPA);
  • polymerase chain reaction (PCR) and Sanger sequencing;
  • quantitative fluorescent PCR (QF-PCR);
  • single nucleotide polymorphism (SNP) genotyping and genome wide association studies (GWAS);
  • and the extraction and analysis of cell free fetal DNA, including non-invasive prenatal testing (NIPT).

Through practice exercises each week, you will evaluate which laboratory investigations are most suitable for a given clinical scenario.

Continue studying with St George’s, University of London

Both Genomic Technologies in Clinical Diagnostics courses draw on the experience of experts in clinical genetics and education at St George’s, University of London.

The two courses will provide you with the teaching component of module 1 of the PGCert in Interpretation and Clinical Application of Genomic Data (PGCert ICAG) from St George’s. To apply for the PGCert ICAG, you must be employed as a genetics trainee within the UK, and hold a national training number (NTN) in clinical genetics.

If you complete both courses on FutureLearn and buy a Certificate of Achievement for each, you will have completed the teaching component of the module, should you apply to study at St George’s.

What topics will you cover?

  • Polymerase chain reaction (PCR)
  • Sanger sequencing
  • Southern blotting
  • Multiplex ligation probe amplification (MLPA)
  • Array comparative genomic hybridisation (array CGH)
  • Karyotyping
  • Fluorescent in situ hybridisation (FISH)
  • Quantitative fluorescent PCR (QF-PCR)
  • Single nucleotide polymorphism (SNP) genotyping and genome wide association studies (GWAS)
  • The extraction and analysis of cell free fetal DNA, including non-invasive prenatal testing (NIPT).

When would you like to start?

  • Date to be announced

What will you achieve?

  • Demonstrate knowledge and applicability of the molecular principles behind PCR/Sanger sequencing; Next Generation Sequencing; MLPA/MS_MLPA; Southern blotting; array CGH; FISH; karyotyping; the extraction and analysis of cell free fetal DNA and QF-PCR
  • Evaluate which laboratory investigation(s) is(are) most suitable for a given clinical scenario
  • Demonstrate an in-depth understanding of the methodology of at least four molecular genetic techniques

Who is the course for?

This course is designed for scientists and healthcare professionals with an interest in obtaining a postgraduate-level understanding of molecular genomic techniques.

If you are new to the field, we recommend that before you start this course, you complete The Genomics Era: the Future of Genetics in Medicine – the first in the Genomics in Healthcare program from St George’s.

Who will you learn with?

Kate Tatton-Brown

I'm a Consultant and Reader in Clinical Genetics. In addition to my clinical role, I am engaged in genomic research and am committed to improving medical education.

Katie Snape

I'm a consultant cancer geneticist at St George's University Hospitals NHS Foundation Trust. My research involved using next generation sequencing technology to identify genes associated with cancer.

Who developed the course?

St George’s is the UK’s only university dedicated to medical and health sciences education, training and research.

Buy a personalised, digital and printed certificate and transcript

You can buy a Certificate of Achievement for this course — a personalised certificate and transcript in both digital and printed formats, to prove what you’ve learnt. A Statement of Participation is also available for this course.

Certificate of Achievement + transcript £79.00

Statement of Participation £34.00

Estimate prices in preferred currency

Charges to your account will be made in GBP. Prices in local currency are provided as a convenience and are only an estimate based on current exchange rates.