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Genomic Technologies in Clinical Diagnostics: Molecular Techniques

Learn how molecular genetic techniques are used to identify the genetic factors that contribute to the development of disease.

21,712 enrolled on this course

Genomic Technologies in Clinical Diagnostics: Molecular Techniques
This course is part of the Genomics in Healthcare program, which will enable you to study genomics at postgraduate level, for CPD or as a gateway to further study.

Powerful new technologies have been driving forward immense and exciting changes in clinical practice.

The days of peering down the microscope to detect chromosome abnormalities are gone, replaced by chromosome analysis at the genomic level. Invasive Down syndrome tests in pregnancy have made way for the evaluation of fetal DNA in maternal blood. And instead of laborious gene-by-gene targeted sequencing, we can now sequence all of our genes in parallel in a single experiment.

The course has been approved for distance-learning continuing professional development (CPD) by the Royal College of Pathologists (RCPath): for 15 CPD credits.

Understand and apply molecular genetic techniques

This postgraduate-level course, in combination with Genomic Technologies in Clinical Diagnostics: Next Generation Sequencing Technologies, will help you understand these new and established genetic technologies, and their application to clinical practice.

This course focuses on molecular techniques. By the end, you will be able to demonstrate knowledge and applicability of the molecular principles behind:

  • array comparative genomic hybridisation (array CGH);
  • karyotyping;
  • fluorescent in situ hybridisation (FISH);
  • Southern blotting;
  • multiplex ligation probe amplification (MLPA);
  • polymerase chain reaction (PCR) and Sanger sequencing;
  • quantitative fluorescent PCR (QF-PCR);
  • single nucleotide polymorphism (SNP) genotyping and genome wide association studies (GWAS);
  • and the extraction and analysis of cell free fetal DNA, including non-invasive prenatal testing (NIPT).

Through practice exercises each week, you will evaluate which laboratory investigations are most suitable for a given clinical scenario.

Continue studying with St George’s, University of London

Both Genomic Technologies in Clinical Diagnostics courses draw on the experience of experts in clinical genetics and education at St George’s, University of London.

The two courses will provide you with the teaching component of module 1 of the PGCert in Interpretation and Clinical Application of Genomic Data (PGCert ICAG) from St George’s. To apply for the PGCert ICAG, you must be employed as a genetics trainee within the UK, and hold a national training number (NTN) in clinical genetics.

If you upgrade and complete both courses on FutureLearn and earn a Certificate of Achievement for each, you will have completed the teaching component of the module, should you apply to study at St George’s.

What topics will you cover?

  • Polymerase chain reaction (PCR)
  • Sanger sequencing
  • Southern blotting
  • Multiplex ligation probe amplification (MLPA)
  • Array comparative genomic hybridisation (array CGH)
  • Karyotyping
  • Fluorescent in situ hybridisation (FISH)
  • Quantitative fluorescent PCR (QF-PCR)
  • Single nucleotide polymorphism (SNP) genotyping and genome wide association studies (GWAS)
  • The extraction and analysis of cell free fetal DNA, including non-invasive prenatal testing (NIPT).

When would you like to start?

Start straight away and learn at your own pace. If the course hasn’t started yet you’ll see the future date listed below.

  • Available now

Learning on this course

You can take this self-guided course and learn at your own pace. On every step of the course you can meet other learners, share your ideas and join in with active discussions in the comments.

What will you achieve?

By the end of the course, you‘ll be able to...

  • Demonstrate knowledge and applicability of the molecular principles behind PCR/Sanger sequencing; Next Generation Sequencing; MLPA/MS_MLPA; Southern blotting; array CGH; FISH; karyotyping; the extraction and analysis of cell free fetal DNA and QF-PCR
  • Evaluate which laboratory investigation(s) is(are) most suitable for a given clinical scenario
  • Demonstrate an in-depth understanding of the methodology of at least four molecular genetic techniques

Who is the course for?

This course is designed for scientists and healthcare professionals with an interest in obtaining a postgraduate-level understanding of molecular genomic techniques.

If you are new to the field, we recommend that before you start this course, you complete The Genomics Era: the Future of Genetics in Medicine – the first in the Genomics in Healthcare program from St George’s.

Who will you learn with?

I'm a Consultant and Reader in Clinical Genetics. In addition to my clinical role, I am engaged in genomic research and am committed to improving medical education.

I'm a consultant cancer geneticist at St George's University Hospitals NHS Foundation Trust. My research involved using next generation sequencing technology to identify genes associated with cancer.

Who developed the course?

St George's, University of London

St George’s is the UK’s only university dedicated to medical and health sciences education, training and research.

Join this course

Start this course for free, upgrade for extra benefits, or buy Unlimited to access this course and hundreds of other short courses for a year.

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  • Access to this course for 5 weeks

Upgrade

$119

Upgrade this course and you will get:

  • Access to this course for as long as it’s on FutureLearn
  • A print and digital Certificate of Achievement once you’re eligible

Unlimited

$189.99 for one year

Buy Unlimited and you will get:

  • Access to this course, and hundreds of other FutureLearn short courses and tests for a year
  • A printable digital Certificate of Achievement on all short courses once you’re eligible
  • The freedom to keep access to any course you've achieved a digital Certificate of Achievement on, for as long as the course exists on FutureLearn
  • The flexibility to complete your choice of short courses in your own time within the year

Find out more about upgrades or Unlimited.

Available until 22 November 2021 at 23:59 (UTC). T&Cs apply.

Learning on FutureLearn

Your learning, your rules

  • Courses are split into weeks, activities, and steps, but you can complete them as quickly or slowly as you like
  • Learn through a mix of bite-sized videos, long- and short-form articles, audio, and practical activities
  • Stay motivated by using the Progress page to keep track of your step completion and assessment scores

Join a global classroom

  • Experience the power of social learning, and get inspired by an international network of learners
  • Share ideas with your peers and course educators on every step of the course
  • Join the conversation by reading, @ing, liking, bookmarking, and replying to comments from others

Map your progress

  • As you work through the course, use notifications and the Progress page to guide your learning
  • Whenever you’re ready, mark each step as complete, you’re in control
  • Complete 90% of course steps and all of the assessments to earn your certificate

Want to know more about learning on FutureLearn? Using FutureLearn

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