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Genomic Technologies in Clinical Diagnostics: Next Generation Sequencing

Understand new and established genomic sequencing technologies, and how to apply them in clinical practice.

27,903 enrolled on this course

  • Duration

    2 weeks
  • Weekly study

    5 hours

Powerful new technologies have been driving forward immense and exciting changes in clinical practice.

The days of peering down the microscope to detect chromosome abnormalities are gone, replaced by chromosome analysis at the genomic level. Invasive Down syndrome tests in pregnancy have made way for the evaluation of fetal DNA in maternal blood. And instead of laborious gene-by-gene targeted sequencing, we can now sequence all of our genes in parallel in a single experiment.

Understand and apply genomic sequencing technologies

This postgraduate-level course, in combination with Genomic Technologies in Clinical Diagnostics: Molecular Techniques, will help you understand these new and established genetic technologies, and their application to clinical practice.

This course focuses on genomic sequencing. By the end, you will be able to:

  • demonstrate an understanding of the molecular principles behind next generation sequencing (NGS) technologies;
  • identify appropriate applications of these technologies to clinical scenarios within both diagnostic and research settings;
  • and evaluate alternative applications of next generation sequencing technologies outside of DNA sequencing, such as RNA seq and ChIP-seq.

Continue studying with St George’s, University of London

Both Genomic Technologies in Clinical Diagnostics courses draw on the experience of experts in clinical genetics and education at St George’s, University of London.

The two courses will provide you with the teaching component of module 1 of the PGCert in Interpretation and Clinical Application of Genomic Data (PGCert ICAG) from St George’s. To apply for the PGCert ICAG, you must be employed as a genetics trainee within the UK, and hold a national training number (NTN) in clinical genetics.

If you complete both courses on FutureLearn and buy a Certificate of Achievement for each, you will have completed the teaching component of the module, should you apply to study at St George’s.

What topics will you cover?

  • The changing landscape of genomics: From Sanger sequencing to Next Generation Sequencing
  • Overview of Next Generation Sequencing platforms and their methodology
  • Targeted resequencing
  • Alignment, variant calling and annotation
  • Other applications of Next Generation Sequencing beyond DNA sequencing
  • Next Generation Sequencing in gene discovery
  • Gene discovery in the research and diagnostics
  • Next Generation Sequencing in clinical diagnostics: Single gene, gene panel sequencing, exome and genome sequencing
  • How to design a gene panel
  • The 100 000 Genomes project
  • The transforming NHS: Genomics in mainstream practice

When would you like to start?

Start straight away and join a global classroom of learners. If the course hasn’t started yet you’ll see the future date listed below.

  • Available now

Learning on this course

On every step of the course you can meet other learners, share your ideas and join in with active discussions in the comments.

What will you achieve?

By the end of the course, you‘ll be able to...

  • Demonstrate an understanding of the molecular principles underlying Next Generation Sequencing (NGS) technologies
  • Identify appropriate applications of these technologies to clinical scenarios within both the diagnostic and research settings
  • Design a panel of genes for analysis using Next Generation Sequencing technologies applicable to a specific clinical phenotype

Who is the course for?

This course is designed for scientists and healthcare professionals with an interest in obtaining a postgraduate-level understanding of genomic sequencing technologies.

If you are completing both Genomic Technologies in Clinical Diagnostics courses, we recommend that you complete Genomic Technologies in Clinical Diagnostics: Molecular Techniques first.

And if you are new to the field, we recommend that before you start either course, you complete The Genomics Era: the Future of Genetics in Medicine – the first in the Genomics in Healthcare program from St George’s.

Who will you learn with?

I'm a consultant cancer geneticist at St George's University Hospitals NHS Foundation Trust. My research involved using next generation sequencing technology to identify genes associated with cancer.

I'm a Consultant and Reader in Clinical Genetics. In addition to my clinical role, I am engaged in genomic research and am committed to improving medical education.

Who developed the course?

St George's, University of London

St George’s is the UK’s only university dedicated to medical and health sciences education, training and research.

Learning on FutureLearn

Your learning, your rules

  • Courses are split into weeks, activities, and steps to help you keep track of your learning
  • Learn through a mix of bite-sized videos, long- and short-form articles, audio, and practical activities
  • Stay motivated by using the Progress page to keep track of your step completion and assessment scores

Join a global classroom

  • Experience the power of social learning, and get inspired by an international network of learners
  • Share ideas with your peers and course educators on every step of the course
  • Join the conversation by reading, @ing, liking, bookmarking, and replying to comments from others

Map your progress

  • As you work through the course, use notifications and the Progress page to guide your learning
  • Whenever you’re ready, mark each step as complete, you’re in control
  • Complete 90% of course steps and all of the assessments to earn your certificate

Want to know more about learning on FutureLearn? Using FutureLearn

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