Skip main navigation

What is IVOST?

Introduction to what Intravenous to Oral Switch (IVOST) is.

Intravenous (IV) to oral switch therapy (IVOST) is the clinical process by which a patients antibiotic prescription is safely changed from an intravenous (IV) to oral regimen at the optimal time in light of clinical improvement and ascertainment of defined evidence-based criteria, preferably supported by easily accessible and clear guidelines within a multidisciplinary team approach to infection care.

This may involve switching to an antibiotic in the same or a different antibiotic class, depending on various clinical and microbiological factors. Historically, most IV antibiotic therapy was prescribed in hospitals so almost all of the published literature is within this context. Increasingly in recent decades, however, patients have been treated with IV antibiotic therapy in outpatient or community settings so consideration of the principles of IVOST in these settings is required. Week 1 will consider this.

In weeks 2 to 4, we will consider the monitoring of complex oral antibiotic regimens within the OPAT setting, often now referred to as complex oral and parenteral antibiotic therapy (COPAT) services. If you are unfamiliar with the principles and benefits of IVOST within the hospital setting, we suggest reading the article in the see also section below, which will be a useful primer.

This article is from the free online

Intravenous to Oral Switch: Within Outpatient Parenteral Antibiotic Therapy (IVOST)

Created by
FutureLearn - Learning For Life

Reach your personal and professional goals

Unlock access to hundreds of expert online courses and degrees from top universities and educators to gain accredited qualifications and professional CV-building certificates.

Join over 18 million learners to launch, switch or build upon your career, all at your own pace, across a wide range of topic areas.

Start Learning now