£199.99 £139.99 for one year of Unlimited learning. Offer ends on 14 November 2022 at 23:59 (UTC). T&Cs apply

Find out more
Outcome of case 5
Skip main navigation

Outcome of case 5

Outcome of case 3
Blurred photo

This patient tolerated Chloramphenicol well for 19 weeks, but then developed blurred vision.

She was referred to ophthalmology who diagnosed optic neuritis, probably secondary to Chloramphenicol. This was stopped and her vision gradually improved over the next 3 months.

In our experience, prolonged oral Chloramphenicol is poorly tolerated by adult patients and should only be used when there are no other oral antibiotic options; serious adverse effects occur even when plasma drug levels are low (as was the case throughout in the patient described in steps 3.4 and 3.5. It is possible that it is better tolerated in children for at least 6 weeks (please find resources in the see also section below).

Following the discontinuation of Chloramphenicol, her knee deteriorated and she was subsequently commenced on Tedizolid 200mg once daily, which was now available to prescribe in the UK.

She subsequently agreed to undergo a knee fusion procedure. At our institution, we apply the same monitoring to Tedizolid as we do for Linezolid (see steps 2.5 onwards and 3.7 and 3.8).

This article is from the free online

Intravenous to Oral Switch: Within Outpatient Parenteral Antibiotic Therapy (IVOST)

Created by
FutureLearn - Learning For Life

Our purpose is to transform access to education.

We offer a diverse selection of courses from leading universities and cultural institutions from around the world. These are delivered one step at a time, and are accessible on mobile, tablet and desktop, so you can fit learning around your life.

We believe learning should be an enjoyable, social experience, so our courses offer the opportunity to discuss what you’re learning with others as you go, helping you make fresh discoveries and form new ideas.
You can unlock new opportunities with unlimited access to hundreds of online short courses for a year by subscribing to our Unlimited package. Build your knowledge with top universities and organisations.

Learn more about how FutureLearn is transforming access to education