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Sistemas y organizaciones AST

Sistemas y organizaciones AST
Hello, everyone. I’m back with the last of four instalments related to antimicrobial susceptibility testing. And today we’re going to talk about systems and organisations.
There are National Medicines Agencies, basically one in each country. In the UK, it’s the NHRA in the US, it’s Food and Drug Administration– FDA. In Sweden it’s Livsmedelsverket. And each of you can go back to your country and find out what the name is in your country. In Europe, the European Medicines Agency, EMA, organises and coordinates all European Medicines agencies.
The European committee on antimicrobial susceptibility test in EUCAST that we’ve talked about previously determines breakpoints for new and for existing agents for Europe. And these are now accepted by all European countries, and many non-European countries. In the US of A, FDA, the Food and Drug Administration, determines breakpoints for the US and seal aside clinical laboratory standards Institute provides technical recommendations. The current uptake of EUCAST’s guidelines in Europe and some other countries are available in maps. You can find those regularly updated on the EUCAST’s website. And the current map is on the link– behind the link, below. So what other relevant organisations might we bring up?
Each country should have a relationship of some sort to external quality control of microbiological procedures. And AST is certainly one of the most important laboratory practises. For those countries that have not organised their own external quality control programme. You can sign up with the UK NEQAS programme. It organises a wide range of EQAs for anything from cytomegalovirus to AST with monthly distributions for many of those things.
And if I didn’t have my numbers wrong, I think there are about 800 laboratories currently signed up, depending on which programme we are talking about. Over the last few years, accreditation authorities have become very important and I think it’s fair to say that all countries in Europe now have an accreditation authority and many of them are organised through a European Central organisation. And most European laboratories either have organised accreditation or are in the process of doing so.
Over the last 10 years, EUCAST has encouraged all countries to form a national AST committee– a NAC. NACs are supposed to help laboratories on a national level to implement good laboratory practises in the field of susceptibility testing, educational activities, advice interpretation of EUCAST. Guidelines sometimes translation of EUCAST’S documents, and all next operate in slightly different ways, but it’s fair to say that in many countries, that NACs have become very important. And if you don’t know what the NAC is doing and who is the chairperson in your country, you can go to the website listed below and find out who you should contact if you would like to do that. So thank you very much.

En este vídeo, el profesor Kahlmeter habla sobre algunas de las organizaciones que están involucradas con el antibiograma y señala recursos y sitios web para estas.



  • EUCAST organiza la microbiología y las enfermedades infecciosas en Europa y en muchos otros países.
  • Para determinar y revisar los puntos de corte
  • Desarrollar metodología para el antibiograma
  • Desarrollar criterios para el control de calidad
  • Educación y formación
  • Promocionar el ECDC (Centro Europeo para la Prevención y el Control de las Enfermedades) y otras entidades sanitarias de la Unión Europea sobre temas relacionados con las pruebas de sensibilidad a los antimicrobianos y la detección de determinantes resistentes relevantes para la sanidad pública.
  • Colaborar con grupos internacionales.
  • Trabajar hacia un consenso internacional, la armonización de los puntos de corte clínicos y las pruebas de sensibilidad a los antimicrobianos.

El mapa que muestra la aceptación actual de las pautas del EUCAST se muestra aquí o en los enlaces «Ver también» a continuación. También tienen un útil boletín que detalla las últimas actualizaciones.

Otras organizaciones incluyen la FDA and CLSI y CLSI en los EE. UU.

UK NEQUA organiza un control de calidad externo para el Reino Unido, pero otros pueden solicitarlo.

Finalmente, se anima a todos los países a formar un NAC (Comité Nacional del Antibiograma) que ayude a los laboratorios a implementar buenas prácticas de laboratorio en el campo de las pruebas de sensibilidad. Encuentra a los presidentes de los NAC haciendo clic aquí.

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Introducción a la microbiología práctica

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