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Autosomal dominant inheritance

In this video, we will learn about Autosomal dominant inheritance where an affected individual has a mutation in one of their gene pairs.

In this video, we learnt about autosomal dominant inheritance, where an affected individual has a mutation in one gene of a pair.

The main features of autosomal dominant inheritance pattern include:

  • Males and females are affected in roughly equal proportions.
  • People in more than one generation are affected.
  • Men and women are both able to pass on the condition to their sons and daughters.

An example of Angelina Jolie's family tree in pedigree form Angelina Jolie’s family tree in pedigree form Click to expand
© St George’s, University of London

The image above depicts a simplified version of Angelina Jolie’s family pedigree, illustrating how an autosomal dominant condition can be passed down through 3 generations.

The actress, who has a pathogenic mutation in BRCA1, lost a number of her immediate family to cancer: her mother, her aunt, and her grandmother.

Talking point

We can see that the emergence of a greater understanding of genomics has already led to some difficult choices. What are, if any, your views on this?

Image: ©“Angelina Jolie – World Economic Forum Annual Meeting Davos 2005” by Remy Steinegger / World Economic Forum. Licensed by CC BY-NC-SA 2.0

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The Genomics Era: the Future of Genetics in Medicine

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