How to retrieve DNA/protein sequences from public repositories

In this video we demonstrate how to download DNA and/or protein sequences from public repositories. We use two popular repositories: NCBI (National Center for Biotechnology and Information) and ENA (European Nucleotide Archive).

Why do we need to know this? Searching for a given gene or protein in a database is where a lot of research starts. For example, imagine you are reading a research paper or a text book on antibiotic resistance in a particular E.coli strain. The paper tells you that the gene or protein responsible for the resistance is called “hpcC”; you want to know the sequence of this gene or protein. How you do find it? Where do you get this information from?

In this video, you will learn where and how to obtain the gene and protein sequences for a gene of interest.

To get the most from this step, we recommend that you try to replicate the steps. You can do so by pausing the video and performing the tasks in your internet browser or you can watch it first and replicate the steps later.