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What Happens After Biologics are Subcutaneously Administrated?


After SC administration, protein drugs can be transported to the systemic circulation directly via blood capillaries or indirectly via the lymphatics, both of which contribute to the absorption of protein drugs from the subcutaneous interstitial region. Small peptides and proteins (<16 kDa) primarily leave the subcutaneous site after injection by diffusion into blood capillaries. Transport of larger proteins from the subcutaneous site involves travel through the interstitium and into the lymphatic system. It has been demonstrated that lymphatic recovery after SC injection directly correlate with molecular mass.

Subsequent to the pervious video, suspension and implant are also presented as alternative dosage forms, exploiting their prolonged release property. In addition, structural modifications such as chimerization, glycosylation and pegylation are perceived from a dispositional point of view to decrease the rate of biologic elimination Most distinctively, biologics are distributed or transported via the lymphatic system, whereas the small molecule drugs are distributed through the capillaries

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Pharmacotherapy: Understanding Biotechnology Products

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