Course: Pharmacotherapy: Understanding Biotechnology Products

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Please take some time to review this article: Mixed views on US biosimilar market Much was expected of biosimilars and their potential to cut the price of originator with savings …

Please take some time to review this essay: The role of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational research of biologics Translational PK/PD has the capacity to integrate data from diverse …

Please take some time to review this essay: Recent Advances in Antisense Oligonucleotide Therapy in Genetic Neuromuscular Diseases ASO-based therapeutics, being able to modulate disease pathways are potential candidates for …

Please take some time to review this article: MedTech Harvard spins out biologics-in-a-pill company with a focus on Type 1 diabetes A formulator of biologics faces a variety of questions …

Please take some time to review this article: Phage display-derived human antibodies in clinical development and therapy Advances in chimerization and humanization technologies have dramatically improved the performance of mAbs, …

As a consultant to the physician, an advocate for the patient and an advisor to the health policy authority, pharmacists should be aware of the available biologic products and reassure …

Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse cellular functions such as cell survival, proliferation, differentiation, and death. As a pro-inflammatory cytokine, TNF is …

When HIV infects a cell, reverse transcriptase copies the viral single-stranded RNA genome into a double-stranded viral DNA. The viral DNA is then integrated into the host chromosomal DNA, which …

Monoclonal antibodies (mAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies have monovalent affinity, in that they bind …

Interleukins are a subset of a larger group of cellular messenger molecules called cytokines, which modulates various cellular functions. Interleukins are not stored within cells but are secreted rapidly and …

Interferons are a group of signaling proteins made and released by host cells as a defensive response to virus infection. In a typical scenario, a virus-infected cell will release interferons …

Two categories of biologic products are covered in this session Erythropoietin (EPO) is a hormone produced primarily by the kidneys. It plays a key role in the production of red …

Antisense oligonucleotides are short, single-stranded DNA molecules that interact with messenger RNA to prevent translation of a target gene. In addition to its unlimited potential for therapeutic applications, antisense technology …

Antocoagulants work via different mechanisms, thrombolytic, antiplatelet or plasminogen activator r-hirudin and drotrecogin are both direct thrombin inhibitors. Tissue plasminogen activator (tPA) is involved in the breakdown of blood clots. …