Skip main navigation

Introduction to PK/PD correlation


Welcome to week 5. This week, we are going to learn PK/PD (pharmacokinetic/pharmacodynamic) Correlations of Biotechnology Products. Pharmacodynamics (PD) is the drug’s action on the body, and Pharmacokinetics (PK) is the reaction of the body system to the drug. When the two elements are combined, the response-time course relationship is established, which enable optimization of dosing regimen for an individual patient or a certain patient population. Expedited drug discovery also becomes possible by being able to predict the PK/PD characteristics of the drug candidate.

Starting with the definition of PK and PD, the latter is defined as drug’s action on the body, and the former is the reaction of the body system to the drug Five commonly used PK/PD correlation models and the accompanied mechanisms are reviewed, The applications of PK/PD modeling are elaborated as follows: Firstly, to elucidate biochemical process and mechanism of biologics action, thereby to guide decision and selection of drug candidates for streamlining the development. Secondly, to assist with the optimization of dosing regimen, and to customize medication for the individual patient or specific population. Please note here DRUG and BIOLOGICS are used interchangeably.

This article is from the free online

Pharmacotherapy: Understanding Biotechnology Products

Created by
FutureLearn - Learning For Life

Reach your personal and professional goals

Unlock access to hundreds of expert online courses and degrees from top universities and educators to gain accredited qualifications and professional CV-building certificates.

Join over 18 million learners to launch, switch or build upon your career, all at your own pace, across a wide range of topic areas.

Start Learning now