Receptor-Mediated Metabolism

Receptor-mediated metabolism is a unique elimination pathway for biologics. It initially entails an interaction of biologics with the membrane receptors on the target structure to elicit pharmacological response. Subsequently, the specific metabolic enzyme is activated to degrade the biologics. This process is saturable and therefore could be dose-dependent for some biologics.

These slides illustrate a unique elimination pathway called receptor-mediated metabolism. The mechanism entails an initial interaction of the biologics with the membrane receptors on the target structure to elicit the pharmacological response. Subsequently, the specific metabolic enzyme is activated to degrade the biologics. This process is enzyme limited and therefore could be dose-dependent; tratuzumab and an M-GCF are given as two examples.