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Anti-Hemophilic Factors

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Most of the recombinant factor VIII products currently on the market incorporate proteins or raw materials derived from either human or animal sources. Next-generation recombinant factor VIII for the treatment of hemophilia A is produced using a protein-free manufacturing process. By excluding proteins or raw materials derived from human or animal sources in the final product, the risk of transmission of potentially infectious agents is greatly diminished.

Recombinant AHF (r-AHF) is a recombinant anti-hemophilic factor derived from Chinese Hamster Ovary (CHO) cell line. Recombinant factor VIII is indicated for Hemophilia A, that of Factor IX for Hemophilia B. A list of then new approved r-AHF (2014) is presented Different brands of r-AHF contain different dose units, caution should be exercised to avoid dispensing error (e.g., Alprolix vs Kogenate vs BeneFix, 1000/2000/3000 iu).

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Pharmacotherapy: Understanding Biotechnology Products

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