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Gram-negative bacteria that cause VAP

Gram-negative bacteria that cause VAP.

Pseudomonas aeruginosa on Meuller Hinton agar

© “Pseudomonas aeruginosa on Meuller Hinton agar” flickr photo by VeeDunn shared under a Creative Commons (BY) license

The most common Gram negative organisms that cause VAP in adults are:

Pseudomonas aeruginosa

Klebsiella pneumoniae

Stenotrophomonas maltophilia

Acinetobacter baumanii

As we have seen in Week 2 empiric antibiotics should have broad spectrum to cover the most likely pathogens.

Tier 1 (First line options: Fluoroquinolones (Ciprofloxacin and Levofloxacin) or Anti Pseudomonal cephalosporins ( Cefepime or Ceftazidime) Piperacillin/Tazobactam

Vincent’s respiratory culture results confirm:

10,000 CFU Pseudomonas aeruginosa and the following susceptibility test results:

7 Antibiotics listed with their Susceptibilities: Levofloxacin - Resistant; Cefepime - Resistant, Aztreonam - Resistant, Meropenem - Resistant, Piperacillin/Tazobactam - Resistant, Tobramycin -Susceptible, Colistin or poylmicin - Susceptible

© BSAC

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Challenges in Antibiotic Resistance: Gram Negative Bacteria

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