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Viewing a bacterial genome: How Chlamydia escaped detection

Dr Adam Reid shows you how genome sequences can be investigated and how whole genome sequencing is the ultimate tool for identifying pathogens

In this video, we show you how genome sequences are visualised using the Artemis software. We give an overview of what a bacterial genome sequences looks like and how resequencing is used to determine differences between similar bacteria. We show how this approach was used to identify how a strain of Chlamydia escaped detection, causing a disease outbreak.

In this video we mention a PCR-based diagnostic test. When used in diagnostic tests the Polymerase Chain Reaction (PCR) allows a small sequence of a genome, for which the sequence is known, to be detected.

OPTIONAL: If you wish to know more about this tool, you can download the Artemis software yourself and try loading the data from this FTP site: ftp://ftp.sanger.ac.uk/pub/pathogens/ar11/FutureLearn/.

For more on analysing bacterial genomes and on the use of Artemis tool, you can follow one of our WGC ACSC courses here: Bacterial Genomes: Accessing and Analysing Microbial Genome Data

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Bacterial Genomes: Disease Outbreaks and Antimicrobial Resistance

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