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Hypercholesterolemia, insulin resistance and brain health


Hypercholesterolemia has been linked to insulin resistance in the brain, leading to oxidative stress and neuron death, which can potentially be prevented by improving the gut microbiome.

Hypercholesterolemia, which is a condition of having too much cholesterol in the body, has been linked to insulin resistance in the brain. Studies have shown that high cholesterol levels in the brain lead to oxidative stress and neuron death. To prevent neurodegeneration, improving the gut microbiome may be a solution, as it has been linked to emotional expression and the production of neurotransmitters. The hormone cortisol, which is produced in response to stress, can increase glucose levels in the blood and lead to damage to organs if secreted over a long period of time.

Review Questions:

  • What is hypercholesterolemia and how is it related to insulin resistance in the brain?
  • What are the potential consequences of high cholesterol levels in the brain?
  • How can improving the gut microbiome help in preventing neurodegeneration?
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Nutrition and Age-Related Chronic Diseases

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