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Case studies

Combining comparative analysis approaches with AMR detection opens the door to a wide range of analyses. One primary research area that used these tools is AMR epidemiology, which focuses on …

Comparative genomics

The transmission of AMR amongst bacterial populations is important to understand, from epidemiological and clinical standpoints When identifying AMR mechanisms like those covered in steps 1.7 and 1.8, it is …

Welcome to Week 3

Week 3 educator Kristy is welcoming you to this week learning In this final week of the course, Kristy introduces the focus on advanced analysis of Antimicrobial Resistance (AMR) data. …

Overview of pros and cons for each method

In this screencast, Conor summarises three primary methods used for genotype-phenotype correlations in antimicrobial resistance research: in-vitro, in-silico, and epidemiological approaches. In-vitro studies involve controlled laboratory experiments where specific genes …

Understanding the CARD output

Watch the screencast with Kristy explaining the output from the Comprehensive Antibiotic Resistance Database (CARD) after analyzing a Salmonella genome for antimicrobial resistance (AMR) genes. The CARD database provides detailed …

How are AMR genes detected?

We have just covered a range of databases that contain bacterial AMR mechanisms and you have heard about their strengths and weaknesses. In this section we are going to cover …

Acquired resistance

Aquired antibiotic resistance In addition to the intrinsic mechanisms of resistance, bacterial pathogens can acquire genes and mutations that mediate resistance to antibiotics. In some cases, bacteria can develop resistance …

Intrinsic resistance

Let’s start with an overview of the mechanisms of resistance Intrinsic resistance refers to the natural resistance of bacterial species to certain antibiotic or family of antibiotics, without the need …

What next from Wellcome Connecting Science?

What you can do next Free Digital Certificate of Achievement This is a Sponsored course, which means that learners can obtain a free Certificate once they become eligible. To be …

Summary of the week 3

Congratulations on reaching the end of the course! In the final week of the course, led by Kristy, the focus was on advanced analysis and applications of antimicrobial resistance (AMR) …

Summary of the week 1

In this week, we covered the foundations of how we link genotypic and phenotypic antimicrobial resistance data together. We covered the genetic basis for antimicrobial resistance in bacteria and gave …

Summary of the week 2

This week’s learning builds upon the Week 1 fundamentals about the antimicrobial resistance Week 2 focused on detecting antimicrobial resistance in genome data. Key topics included evaluating three major AMR …