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Introducing ResistoXplorer

The name ResistoXplorer is derived from the connection of two words: Resistome and Explorer. This denomination explains the purpose behind it, which is to allow visualisation, statistical and exploratory analysis …

Downstream Analysis of Resistome data

To understand the downstream analysis of data, let’s imagine a story together. Of course, this specific case is fictional, but it could very well be real! “Dr. Patricia just started …

Differential abundance testing

One of the main aims of the metagenomic-based resistome studies is to identify significant differences in resistance gene abundances between samples. Although it sounds straightforward, several technical challenges remain, most …

Beta diversity (or Ordination) analysis

Beta diversity characterises differences in the ARG or resistome composition between samples. There are several beta diversity indices/measures that can be used to generate a distance or dissimilarity scores to …

Diversity profiling

Metagenomic resistome data are multi-dimensional, often represented by hundreds or thousands of different ARGs, and therefore deducing meaningful results is not only dependent on the abundance of single ARGs, but …

Visual Profiling

One of the most basic and first questions that arise in metagenomics-based resistome studies are what antimicrobial resistance genes (ARGs) are there and in what proportion are they present in …

Data Normalisation in ResistoXplorer

In this video, we will demonstrate how to perform various types of normalisation on resistome data in ResistoXplorer. When the video is playing, please follow along on your computer!