Course: Exploring the Landscape of Antibiotic Resistance in Microbiomes

In the previous steps, we have glanced over the steps that are required to analyze resistomes. You will probably remember this image: We will now go deeper into it, starting …

In recent years, the response to the AMR crisis has been spearheaded by leading international organizations such as the United Nations (UN) and the World Health Organization (WHO). In 2016, …

Antibiotics did not come easy. Misuse and overuse of antibiotics are accelerating the development and spread of antibiotic resistance, and making antibiotics ineffective. Dr Ulf Dahle revisits the early history …

In this video Professor Fernanda Petersen discusses the development of antibiotic resistance as a natural evolutionary response of microbes to antibiotic exposure. The landscape of antibiotic and other antimicrobial resistance …

We have now arrived at the end of our course. We hope that this course has helped you to equip you with important skills in the field, either to better …

We finally reached step 4 – downstream analysis! This is the step in which we try to make sense and interpret the data obtained. And this is precisely why ResistoXplorer …

To continue on the topic of computational resources, we invite Dr. Tsute (George) Chen to our series ‘An expert’s view’. Dr. Chen is an expert microbiologist and bioinformatician who has …

Now we have annotated the ARGs present in the samples – great! This data can be then analyzed for abundance, diversity, and used to draw comparison across samples. So far, …

The field of metagenomics evolves very rapidly, and resources we have available for analyses allow us to reassess the methods used in the past. To finish our series ‘An expert’s …

High-throughput sequencing allows us to achieve our objective, which is to characterize the resistance profiles of microbial communities. Nowadays, this can be performed reliably and at a fraction of the …

In this video, Professor Fernanda Petersen introduces general principles, advantages and limitations of culture-based and culture-independent methods to study resistomes in microbial communities.

In the previous step, we have seen how we can identify and visualise patterns or groups (if present) in our high-dimensional resistome data using ordination analysis. Another very commonly used …

It is impossible to talk about antimicrobial resistance without highlighting mechanisms used by bacteria for gene exchange. What are these mechanisms and how can they impact bacterial life? In this …

In this video, we will demonstrate how to remove unwanted or uninformative features (antimicrobial resistance genes) from the resistome data using ResistoXplorer. When the video is playing, feel free to …

In this video, we will demonstrate how to format and upload the resistome data in ResistoXplorer. When the video is playing, feel free to follow along on your computer! For …