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Antibiotics in use: not accidental

Antibiotics did not come easy. Misuse and overuse of antibiotics are accelerating the development and spread of antibiotic resistance, and making antibiotics ineffective. Dr Ulf Dahle revisits the early history …

Farewell

We have now arrived at the end of our course. We hope that this course has helped you to equip you with important skills in the field, either to better …

Downstream analyses

We finally reached step 4 – downstream analysis! This is the step in which we try to make sense and interpret the data obtained. And this is precisely why ResistoXplorer …

Normalization and differential analysis

Now we have annotated the ARGs present in the samples – great! This data can be then analyzed for abundance, diversity, and used to draw comparison across samples. So far, …

DNA sequencing

High-throughput sequencing allows us to achieve our objective, which is to characterize the resistance profiles of microbial communities. Nowadays, this can be performed reliably and at a fraction of the …

Exploring resistomes in microbial communities

In this video, Professor Fernanda Petersen introduces general principles, advantages and limitations of culture-based and culture-independent methods to study resistomes in microbial communities.

Clustering and correlation analysis

In the previous step, we have seen how we can identify and visualise patterns or groups (if present) in our high-dimensional resistome data using ordination analysis. Another very commonly used …

Data Filtering in ResistoXplorer

In this video, we will demonstrate how to remove unwanted or uninformative features (antimicrobial resistance genes) from the resistome data using ResistoXplorer. When the video is playing, feel free to …

Introducing ResistoXplorer

The name ResistoXplorer is derived from the connection of two words: Resistome and Explorer. This denomination explains the purpose behind it, which is to allow visualisation, statistical and exploratory analysis …