Course: Introduction to Translational Research: Connecting Scientists and Medical Doctors

We hope you enjoyed this free online course from Taipei Medical University (TMU). In TMU, the Ph.D. Program for Translational Medicine is an innovative training program in clinical researches that …

What is a protocol? A protocol describes the objectives, design, methodology, population, statistical considerations, ethical conduct, and organization of a clinical trial. In this video, Dr. Castro will explain the …

Clinical research breaks down into four phases. In this video, Dr. Castro will explain scopes of each phase, including the survival rates of clinical trials.

In the last week of this course, Dr. Castro will talk about clinical trials. It is the final step before a new drug can hit the market. TMU has organized …

Drug discovery helps us to fight diseases and alleviate suffering. To combat serious or new emerging disease (e.g. cancers and Ebola virus), an effective platform for drug discovery is necessary. …

Main concept: Turning the receptor off Just because a signal activates the EGF receptor, it needs to be turned off as well. But the question is ‘how’? The strategy is …

Binding of EGFR to its cognate ligands leads to autophosphorylation of the receptor itself by the tyrosine kinase activity. A variety of signal transduction pathways are subsequently activated, which are …

In this animation, you can see how the binding between EGF and EGFR stimulates the signal transduction in a cell.

Welcome to Week 4. This week we will talk about how to identify and optimize a molecule drug. Drug discovery is a huge topic. Instead, we will use several cases …

LDL-cholesterol is known as “bad cholesterol” because at high levels it can cause plaque to accumulate on your artery walls and increase the risk of heart attack or stroke. Statins …

We already introduced several high throughput approaches to identify disease-associated genes. The next question is: Are these genes the real target for the disease? This means whether the gene mutations …

Protein biomarkers discovery integrates many components of translational medicine. In this video, Prof. Cheng will introduce two major proteomics techniques for discovering protein biomarkers: 2-D electrophoresis MALDI-TOF Mass Spectrometry Educator: …

Biomarker discovery A biomarker is defined as a measurable indicator of a particular disease or physiological state. With improving technological advances, such as genome-wide gene expression profiling and advanced bioinformatics, …

In this video, Prof. Shih will explain current major techniques of RNA profiling, especially for the target identification. Three major techniques will be introduced: Real time-quantitative PCR cDNA microarray RNA …

The normal cellular function depends on the accurate expression of numerous protein coding RNAs (mRNAs) and non-coding RNAs (ncRNAs). Mutations that disrupt the production or activity of either the RNA …