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Further study at Taipei Medical University

We hope you enjoyed this free online course from Taipei Medical University (TMU). In TMU, the Ph.D. Program for Translational Medicine is an innovative training program in clinical researches that …

Protocol elements of a clinical trial

What is a protocol? A protocol describes the objectives, design, methodology, population, statistical considerations, ethical conduct, and organization of a clinical trial. In this video, Dr. Castro will explain the …

Development regulation

Clinical research breaks down into four phases. In this video, Dr. Castro will explain scopes of each phase, including the survival rates of clinical trials.

Introduction to clinical trials

In the last week of this course, Dr. Castro will talk about clinical trials. It is the final step before a new drug can hit the market. TMU has organized …

Conclusion and support information

Drug discovery helps us to fight diseases and alleviate suffering. To combat serious or new emerging disease (e.g. cancers and Ebola virus), an effective platform for drug discovery is necessary. …

EGFR drug design

Main concept: Turning the receptor off Just because a signal activates the EGF receptor, it needs to be turned off as well. But the question is ‘how’? The strategy is …

EGFR and tumor cells

Binding of EGFR to its cognate ligands leads to autophosphorylation of the receptor itself by the tyrosine kinase activity. A variety of signal transduction pathways are subsequently activated, which are …

Introduction to molecule drug discovery

Welcome to Week 4. This week we will talk about how to identify and optimize a molecule drug. Drug discovery is a huge topic. Instead, we will use several cases …

Case study: PCSK9 cholesterol-lowing drugs

LDL-cholesterol is known as “bad cholesterol” because at high levels it can cause plaque to accumulate on your artery walls and increase the risk of heart attack or stroke. Statins …

Techniques of RNA analysis for target identification

In this video, Prof. Shih will explain current major techniques of RNA profiling, especially for the target identification. Three major techniques will be introduced: Real time-quantitative PCR cDNA microarray RNA …

Roles of RNAs in disease pathophysiology

The normal cellular function depends on the accurate expression of numerous protein coding RNAs (mRNAs) and non-coding RNAs (ncRNAs). Mutations that disrupt the production or activity of either the RNA …