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Genetic predisposition to some MSK conditions

Most musculoskeletal disorders are polygenic disorders, with both genetic and environmental factors playing roles.

Most musculoskeletal disorders are polygenic disorders, with both genetic and environmental factors playing roles. The genetic influence and familial predisposition may be more considerable than expected. There is some evidence suggesting that knee bone size may be important in the development of knee Osteoarthritis. Knee bone size is under strong genetic control and is higher in the offspring of those with severe OA. A higher BMI can induce larger knee subchondral bone size or that knee subchondral bone may respond to higher loads by expansion of the joint surface area.

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Musculoskeletal Health: A Public Health Approach

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