Welcome to the project
In this step we will explore two plasmid sequences found in Shigella known to carry antibiotic resistance genes. We will introduce you to the project tasks and guide your preparation …
Course: Bacterial Genomes III: Comparative Genomics using Artemis Comparison Tool (ACT)
Comparing Two FASTA Files
In this exercise we will compare two Staphylococcus aureus genomes in ACT and investigate the number of differences, also called synteny breaks. The first sequence we will download is the …
What is ACT?
When analysing genome data, it can be very informative to investigate the differences between closely related organisms. Knowing these differences will help you to understand the biology of the organism …
Introductions
Here at the Wellcome Genome Campus, near Cambridge, UK, and in Overseas locations, we welcome learners from all over the world to our Advanced Courses and Scientific Conferences. Today we …
FAQs for this course
Here are some Frequently Asked Questions for this course. This step will be linked back from the relevant steps and you can always get back to it later I am …
Acknowledgements
Many thanks to all those who are and were involved in the course Bacterial Genomes: Comparative Genomics using ACT. Course Lead Educators and Lead Developers Dr. Anna Protasio, Dr. Christine …
Using ACT to find pseudogenes in two Mycobacterial species
Please note: Our previous course “Bacterial Genomes: accessing and analysing microbial genome data” is a recommended pre-requisite for this part of the course. It is open for joining and access …
Interview with Dr. Kate Baker – Discussion of the Shigella project
Dr Kate Baker was interviewed by Dr Christine Boinett about her research, which further explains the peer project you have just undertaken and putting it into context. You will find …
Putting your ACT skills into practice
This week is split into two parts. The first is looking back at the two Mycobacterial species we used in the previous course, Bacterial Genomes: Accessing and Analysing Microbial Genome …
Interview with Dr Alison Mather
In this step, you will watch an interview with Dr Alison Mather Dr Alison Mather was interviewed by Martin Aslett about her research. Alison will show some of the applications …
Interview with Professor Nicholas Thomson – Why ACT?
In this step, we will hear an interview with Professor Nicholas Thomson In this video, Professor Nicholas Thomson, Wellcome Sanger Institute and London School of Hygiene and Tropical Medicine, talks …
What is Comparative Genomics
Put simply, comparative genomics is the comparison of two or more genome sequences This allows researchers to identify sequences of DNA that are shared, or ‘conserved’, between these genomes. Likewise, …
Interview with Sushmita Sridhar
In this step you will watch an interview with Sushmita Sridhar, a PhD student at the Wellcome Sanger Institute and the Department of Medicine at the University of Cambridge. In …
Comparative Genomics: Useful Terms and Concepts
We have summarised here some of the key terms that you will come across when studying comparative genomics. The definitions are given in the context of bioinformatics. Accession number It …
Getting you started
Here it is what you will need for this course Although a lot of the course content can be accessed through a mobile device, this course relies heavily on screencasts …
These articles are from the online course:
Bacterial Genomes III: Comparative Genomics using Artemis Comparison Tool (ACT)