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Further reading on the different MODY subtypes

If you would like to know more about the different MODY subtypes, we suggest you look at this material: Clinical features, diagnosis and management of maternally inherited diabetes and deafness …

A genetic diagnosis of HNF1A MODY

Dan’s family wanted to clarify the cause of his diabetes, so they contacted us via our Diabetes Genes website and we organised genetic testing for him. As mentioned in Week …

Monogenic diabetes examples

What is the chance that my children will also have diabetes? Will my grandchildren also be at risk of this type of diabetes? These are the questions patients often ask, …

How do we find polygenic genes?

You’ve learnt about the genetic architecture of type 1 and type 2 diabetes, but how have we made these discoveries and how do we go about finding new genes involved? …

The human genome unlocked

One of the most exciting developments in biology and medicine is happening at a rapid pace right now. Genome scientists and their industrial partners are developing the technology and tools …

What is the prevalence of diabetes?

In this step we will consider the wider problem of diabetes increasing across the world. International Diabetes Federation. IDF Diabetes, 7 ed. Brussels, Belgium: International Diabetes Federation, 2015. According to …

The neurological phenotype

KATP channels are expressed in the brain, nerve and muscle as well as the pancreas. <img src="https://ugc.futurelearn.com/uploads/assets/f5/4e/f54edd00-6315-4124-be88-2b18983ba8b5.jpg" alt="KATP Channel Function. Neuron: modulate electrical activity and transmitter release at brain synapses. …

A new treatment for neonatal diabetes

The optimal treatment for patients with KCNJ11 neonatal diabetes is high doses of sulphonylureas which enable patients to release insulin in response to raised blood glucose levels after a meal. …

Why was a genetic diagnosis so important?

Diabetes wasn’t the only issue for Jack. Over a number of months his family began noticing some developmental delay. He wasn’t developing as my other child had. By a year …

Investigating the cause of Jack’s diabetes

Jack underwent genetic testing to investigate the cause of his diabetes which indicated a mutation in the KCNJ11 gene, a gene important for regulating insulin secretion, confirming a diagnosis of …

Different types of diabetes

What is Type 1 diabetes? Type 1 diabetes is an autoimmune disease that occurs when T cells attack and destroy most of the beta cells in the pancreas that are …