Course: Genomic Medicine: Transforming Patient Care in Diabetes

If you would like to know more about the different MODY subtypes, we suggest you look at this material: Clinical features, diagnosis and management of maternally inherited diabetes and deafness …

It is currently too expensive and unnecessary to offer genetic testing to everyone with diabetes so we need to identify those patients most likely to have a monogenic cause of …

Dan’s family wanted to clarify the cause of his diabetes, so they contacted us via our Diabetes Genes website and we organised genetic testing for him. As mentioned in Week …

What is the chance that my children will also have diabetes? Will my grandchildren also be at risk of this type of diabetes? These are the questions patients often ask, …

We have developed an online MODY probability calculator which can give a probability score of a patient having MODY, and a Diabetes Diagnostics App (available for iOS and Android) which …

You’ve learnt about the genetic architecture of type 1 and type 2 diabetes, but how have we made these discoveries and how do we go about finding new genes involved? …

One of the most exciting developments in biology and medicine is happening at a rapid pace right now. Genome scientists and their industrial partners are developing the technology and tools …

Genetic risk in type 1 diabetes According to Diabetes UK: ‘Although more than 85% of type 1 diabetes occurs in individuals with no previous first degree family history, the risk …

In this step we will consider the wider problem of diabetes increasing across the world. International Diabetes Federation. IDF Diabetes, 7 ed. Brussels, Belgium: International Diabetes Federation, 2015. According to …

KATP channels are expressed in the brain, nerve and muscle as well as the pancreas. <img src="https://ugc.futurelearn.com/uploads/assets/f5/4e/f54edd00-6315-4124-be88-2b18983ba8b5.jpg" alt="KATP Channel Function. Neuron: modulate electrical activity and transmitter release at brain synapses. …

The optimal treatment for patients with KCNJ11 neonatal diabetes is high doses of sulphonylureas which enable patients to release insulin in response to raised blood glucose levels after a meal. …

Diabetes wasn’t the only issue for Jack. Over a number of months his family began noticing some developmental delay. He wasn’t developing as my other child had. By a year …

Jack underwent genetic testing to investigate the cause of his diabetes which indicated a mutation in the KCNJ11 gene, a gene important for regulating insulin secretion, confirming a diagnosis of …

What is Type 1 diabetes? Type 1 diabetes is an autoimmune disease that occurs when T cells attack and destroy most of the beta cells in the pancreas that are …