A Framework for Evidence Base Network

So the idea that I had for legends is that it should be similar to the Large Hadron Collider.

So the Large Hadron Collider is a project where a lot of particles physicists came together and decided and, instead of each one of them doing a a small bit of research on themselves, together they would build the machine that would generate the evidence. And I hope in legend we can do the same where we can all get together and start working on this evidence generating machine. And so that evidence generating machine, we basically hold a lot of research questions that we want answers. So I was talking about these depression research questions. But we’re gonna add hybrid, we’re adding hypertension as a next area of questions that will answer. We’re working on improving new methods.

We’re working on expanding the number of databases that are involved there. And I hope that we can include the Taiwanese database at one point as well. And that would generates a large evidence base. Of course from that evidence base which I hope, we can make this thing publicly available, there are some snafus there. We don’t want people to do data dredging but anyway, well, assuming that it will be publicly available, of course, you can write lots of papers on it. We can build a web app like I just gave you the URL for it. But I’m also hoping that we get something like The Weather Channel. So The Weather Channel is this, a channel in the U.S. It’s a company.

It doesn’t actually predict the weather or collect any data. The National Weather Service does that. It collects all the data. It runs all the fancy model and then it puts all that information in a evidence base. And then the Weather Channel, all the Weather Channel does, is it picks up that database and then presents it in a way that is usable to the end-user. And so we hope actually the people will start doing that because we know that it doesn’t, Dr. Westbrook has already showed just having the information somewhere is not enough. We need to make sure that somehow it reaches the doctor and the patients. So closing remark. Current published evidence from observational research is unreliable.

Because of study bias publication bias and P-hacking and we can address this by, well, using more advanced method by measuring bias and calibrating effect estimates and by answering many questions at one, and publishing that as a unit. And legend will apply all of these principles in practices. And with that, at the end, thank you very much.