Learn with case studies of ADR events

We will see 6 more examples in SOAP format in this video. Please observe each case and ponder why the plan, suggestion, and adjustment being given.

The eighth case

A 53-year-old male developed developed seizure and conscious change. He previously received ertapenem 1000 mg IV QD for UTI since 5 days ago. He also received two 7-day course of Cefixime 150 mg PO every 12 hours on 2/3 (27 days ago) and 2/18 (12 days ago). Urine culture grew E. Coli, serum creatinine was elevated to 2.47 and estimated creatinine clearance was about 36.1 mL/min. Neutrophil count elevated to 85%.

Below are some of the relevant information:

Ertapenem related seizure has an incidence rate of 0.5%.

Brain CT scan showed no intracranial space occupying lesion, nor intracranial hemorrhage.

The TVGH pharmacists switched to Flumarin (flomoxef 1 g IV every 8 hours) for the next 2 days and taper to every 12 hours for 12 days after that.