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The importance of experimental design

Experimental design is important in any scientific study. Ideally we would measure one source of variation while controlling all others. However, in metabolomics it is not always possible to control …

Introduction to mass spectrometry

Mass spectrometry is one of the analytical techniques applied in metabolomics. Dr Catherine Winder provides an introduction to mass spectrometry and explains why its a valuable tool to study the …

Beyond principal component analysis

The high-dimensional and wide data tables that are encountered in metabolomics can be difficult to analyse, but the metabolomics community is now routinely applying many techniques to interrogate these large …

The application of quality control samples

Quality assurance and quality control provides a mechanism to ensure that a scientific process meets the predefined criteria. In metabolomics the application of quality control samples and their use in …

Q & A

Dr Warwick Dunn answers your questions from Weeks 1 and 2.

Metabolomics Glossary

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z A Absolute quantification Analyte …

Coverage of the metabolome

The metabolome is a complex and dynamic system and it is challenging to measure all of the metabolites in the metabolome. The objective of an untargeted metabolomics experiment is to …

Metabolic turnover and sampling the metabolome

Metabolism is in constant flux and the turnover of metabolites is fast compared to the transcriptome and proteome. Samples that are metabolically active such as cells, or tissues contain enzymes …

NERC Metabolomics Facility – NBAF Birmingham

NBAF-B, at the University of Birmingham, is one of the four ‘nodes’ of the NERC Biomolecular Analysis Facility (www.nbaf.nerc.ac.uk) and provides the UK environmental science community with access to state-of-the-art …

The Phenome Centre Birmingham

What is the Phenome Centre Birmingham? Phenome Centre Birmingham is an £8million MRC, University of Birmingham and analytical instrument company funded center to support large-scale metabolic phenotyping in the clinical …

Studying for a PhD in Clinical Metabolomics

Riccardo Di Guida describes why he decided to study for a PhD at the University of Birmingham and the application and future impact of his research within the clinical sciences.