Course: Metabolomics: Understanding Metabolism in the 21st Century

Martin Jones describes his reasons for conducting a PhD in metabolomics, the application of his research within the environmental sciences and how his research will impact in the future.

Over the next few steps we will provide several examples of how scientists working in different biological areas are applying metabolomics to facilitate their research. In this first examples Professor …

The discovery based (hypothesis generating) experiment is the first step of the scientific study. Further studies should be performed to validate the discovery and test the hypothesis. Professor Warwick Dunn …

Discovery based, or also referred to as hypothesis generating studies have evolved over the past 15 years with the increase in ‘omics based studies. Hundreds to thousands of metabolites are …

There are three analytical chemistry strategies applied in metabolomics – untargeted, semi-targeted and targeted. Both untargeted and semi-targeted approaches are applied in hypothesis-generating studies, while targeted assays are usually applied …

Dr Catherine Winder introduces the topics that will be covered in the second week of the course. Mark as complete Remember to click the Mark as complete button when you …

Professor Mark Viant responds to your questions from Week 1.

The central dogma of biology provides the framework for the flow of genetic material from the gene to the transcript, protein and metabolite. However, in metabolism, metabolites act as regulators …

Metabolism is the collection of chemical reactions performed within a biological system to maintain life. These enzyme catalysed reactions are organised into metabolic pathways and are classified as catabolic (the …

Studying the metabolome is advantageous for several reasons including, The metabolome provides the closest link to the phenotype of an organism The analytical approaches are transferable across different biological systems …

In the previous steps we outlined that a biological system is constructed with biochemical components including metabolites and genes, and the biological function or phenotype is controlled by the interactions …

So far, we have discuss how different components (metabolites and enzymes) interact in metabolism and how these interactions help us to investigate the function and phenotype of biological systems. We …

Although metabolomics has reached maturity, it is the newest ‘omics technique and trails genomics and proteomics in terms of the number of publications and the current estimated market value. The …

Metabolomics is a non-biased experimental approach that attempts to measure all of the metabolites in the biological sample. Metabolomics studies are often described as untargeted or discovery-based and focus on …