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Skip to 0 minutes and 13 seconds By the end of this presentation you should be able to: - Explain the natural history of trachoma, and - Describe its clinical features Trachoma is the leading infectious cause of blindness. It has been around for a long time and was documented in ancient Egyptian and Chinese writings. The cause of the infection is a bacterium called Chlamydia trachomatis which grows and reproduces inside the cells of its hosts. Specifically it is the A, B, Ba and C variations - known as serovars - that are associated with trachoma eye disease. Other serovars, D to K, are associated with genital chlamydial infection. The Chlamydia sp. bacterium has a unique life cycle. It starts as an inert, but infectious, particle called an elementary body (EB).

Skip to 1 minute and 2 seconds This EB can enter into a human cell enclosed in a vesicle. A vesicle is a membranous sac containing fluid. Within just 2 hours the EB changes into an active reticulate body (RB) and begins to multiply rapidly within the vesicle. The RB go on replicating and can occupy up to 90% of a cell. This is known as an - inclusion body- when seen through a microscope. About 48 hours after a cell is infected it ruptures, and releases a large number of elementary bodies and active reticulate bodies into the surrounding tissues. This spreads the infection to more cells. We can detect chlamydial infection

Skip to 1 minute and 47 seconds in the laboratory using a range of methods: - Microscopy: Smears of human tissue are stained and examined for inclusion bodies through a microscope. - Cell culture: this is a series of complex steps to isolate and identify infected cells. Diagnosis is confirmed by microscopy. - A blood test - serology - and indirect immunofluorescent assay can be used to detect anti-chlamydial antibodies in serum or tears. - More recent tests include the Nucleic Acid amplification test which identifies the presence of the chlamydial DNA. The highest positive levels of chlamydia infection are found in young children living in communities affected by trachoma.

Skip to 2 minutes and 37 seconds There is a challenge with using laboratory tests to identify chlamydial infection. The test results sometimes contradict the clinical features of trachoma we see in patients. Sometimes we get a positive result for someone with clinically - normal - eyes. On the other hand some people will show signs of clinically active trachoma whilst receiving a negative test result. These variations occur because the development and resolution of clinical features lags behind the start and finish of a positive laboratory test. We also don’t yet have an accurate, quick and inexpensive way to test for infection in the field, at the community level.

Skip to 3 minutes and 18 seconds So because of these two issues, the best way to monitor the level of trachoma disease in communities is to examine people for the presence of clinical features rather than to rely on laboratory tests.

Skip to 3 minutes and 32 seconds The clinical features we see in people with trachoma disease are caused by their physical response to infection by Chlamydia trachomatis. There are two major phases to the disease. First, the active or inflammatory trachoma, and then the cicatricial or late scarring trachoma.

Skip to 3 minutes and 51 seconds In communities affected by trachoma, we find that active inflammatory disease mainly resides in children. Children who have repeated or persistent episodes of chlamydial infection develop follicles and papillae on their conjunctiva. The conjunctiva is a thin tissue which lines the inside of the eyelids and covers the white part of the eye, the sclera.

Skip to 4 minutes and 15 seconds Follicles are yellow or white spots containing lymphoid cells. Papillae are swollen, inflamed membranes around the small blood vessels on the conjunctiva. In severe cases the inflammation can cause the conjunctiva to obscure these blood vessels. New blood vessels may occasionally grow onto the cornea - the transparent front part of the eye. This produces a corneal pannus - a growth of connective tissue.

Skip to 4 minutes and 45 seconds A child with trachoma often has no symptoms. The common symptoms children with trachoma do complain of,

Skip to 4 minutes and 51 seconds are: - Irritation of the eyes. - Mucus or even pussy discharge from the eyes. - Swelling of the upper eyelids.

Skip to 5 minutes and 2 seconds Multiple infection[s] and episodes of inflammation over time [can] result in the cicatricial or scarring phase of trachoma. This can begin in adolesence or adulthood. Trachomatous scarring starts with star-like scars in the position of old follicles. These small scars eventually coalesce into larger and deeper scarring. In the early stages the eyelids are not distorted and vision is normal. If the scarring progresses it can cause the eyelashes to turn inwards. This is called trichaisis. These in-turned eyelashes rub on the cornea causing pain. A combination of trichiasis, lack of tear production and secondary bacterial infection can all lead to corneal scarring, loss of vision and eventually irreversible blindness.

Skip to 5 minutes and 50 seconds The World Health Organization has produced a simplified classification scheme for assessing trachoma at the community level based on clinical signs of disease. Trachoma is spread through direct contact between people or by flies. Flies - particularly Musca sorbens which is an eye seeking fly - spread chlamydial infection as they land and feed on ocular and nasal discharge on people’s faces, especially young children. People also transmit the infection through touch and by sharing cloths. Facial discharge and lack of a clean face is related to the presence of infection. Mothers and women in close contact with small children with active disease are at risk of being infected.

Skip to 6 minutes and 44 seconds Overcrowding, poor personal hygiene, lack of water to clean faces and inadequate community sanitation are further risk factors for the spread of trachoma within communities.

Skip to 6 minutes and 57 seconds Musca sorbens flies breed in human and animal faeces. We can reduce the risk of transmission of trachoma by improving environmental sanitation. In summary, - Trachoma is caused by infection by an intracellular bacterium called Chlamydia trachomatis - Infection results in inflammation of the conjunctiva. - Active trachoma causes follicles and papillae in the conjunctiva - Cicatricial trachoma results in scarring of the conjunctiva. Scarring can cause the eyelashes to turn inwards and scrape on the cornea. This is known as trichiasis. - With repeated and persistent chlamydial infection, trichiasis can lead to corneal scarring and blindness.

Skip to 7 minutes and 50 seconds Children in communities affected by trachoma have the highest positive levels of chlamydial infection - Trachoma is spread between people through contact with infected ocular and nasal discharge in overcrowded settings with poor hygiene - Flies also spread trachoma in communities with poor environmental sanitation.

Trachoma: An introduction

Trachoma is an infectious eye disease. It is also a very old disease that has been well-documented throughout history. Some of the earliest trachoma maps show that it was found across most countries globally. In recent years, the number of countries affected by trachoma has reduced, but it still remains the main infectious blinding eye disease, with over 181 million people at risk, across 42 countries.

At an individual level, the disease is a painful, disabling condition that starts in childhood and can progressively cause blindness. The impact of this contagious disease can be devastating for the affected person, their family and their community. Trachoma is most prevalent in rural, dry, dusty regions; often affecting communities already struggling with poverty.

We are in a unique position at present! We have an effective antibiotic to treat the disease and control its spread. We also can prevent blindness as a consequence of trachoma through surgery. We have a global strategic plan and simultaneous national level planning to mobilise partners and resources to treat and prevent trachoma. We can begin to have an ambition - to eliminate trachoma!

The planned strategy that needs to be implemented is known as SAFE. This acronym denotes the key activities that need to be delivered at both community and individual levels to achieve our goal of elimination by the year 2020.

  • S - trichiasis surgery to prevent blindness
  • A - antibiotic distribution to clear infection
  • F - facial cleanliness to reduce transmission
  • E - environmental improvement to ensure sustainable elimination of the disease

As you watch the video, consider why trachoma may have disappeared from some regions of the world (e.g Europe, America, parts of Asia) and not in others?

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Eliminating Trachoma

London School of Hygiene & Tropical Medicine

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