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Skip to 0 minutes and 14 seconds Now let me ask a question: Instead of using proteins, can we use peptide as biologics? And the answer is, of course, yes.

Skip to 0 minutes and 33 seconds What is a peptide? What is a small peptide? Oligopeptide is a short peptide in contrast with a long chain peptide.

Skip to 0 minutes and 47 seconds And technologies are available to produce oligopeptide smaller peptide, shorter peptide by bio organic synthesis, from natural resources or vir bio engineering process. And there are advantages of peptide versus protein. For example, they have similar functions but the oligopeptide has better tissue permeability because of the smaller size. The production has higher yield. And the peptide is easier to separate. It has higher purity. It has better stability. And overall it’s more cost-effective.

Skip to 1 minute and 43 seconds Applications of peptide. Pharmacologically, they function as protein receptor agonists or antagonists, just like protein biologics.

Skip to 1 minute and 59 seconds Many peptides function as hormones, neurotransmitters or for example, a natural painkiller. Endorphin is actually a peptide of 31 amino acid. And as you know, insulin is actually a peptide as well.

Skip to 2 minutes and 22 seconds And peptides are used as skin care ingredient in the anti-wrinkle product in a very lucrative cosmetic industry. And the older women and men would love this type of product for skincare to get rid of the wrinkles.

Skip to 2 minutes and 45 seconds Protein is a peptide but not all peptides are proteins.

Peptide Technology

While peptides are naturally-occurring, there are synthetic peptides that can trigger pharmacological effect of proteins or organic compounds. Peptides are responsible for regulating a variety of cell functions, including metabolism, digestion, respiration, and immune response. In addition, peptides have quickly become some of the most sought-after ingredients in skincare. Modifications introduced via rational design have led to improved physicochemical and pharmacological properties of therapeutic peptides.

Peptide vs Protein Peptides received research interest initially because of the search for small protein fragments with retained biological functionality. A peptide can be synthesized from the constituent amino acids linked together in a chain-like structure. Being largely two dimensional in structure, it is presumably more stable than its three-dimensional counterpart. The smaller molecular size may actually facilitate its transport and distribution in the biological system.

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Pharmacotherapy: Understanding Biotechnology Products

Taipei Medical University