Animation of single-cell DNA template strand sequencing (Strand-seq)

The single-cell DNA template strand sequencing technique – Strand-seq for short – is a method to identify the original parental DNA template strands in daughter cells following cell division.

Strand-seq is a very powerful tool for not just detecting DNA strand inheritance patterns, but also for assessing genomic instability at the single cell level. This can be done with a much higher sensitivity and level of resolution than was previously possible. This animation explains the principle of Strand-seq and also briefly introduces the main applications of this method.