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The relationship between Volume, Clearance, and k

The relationship between Volume, Clearance, and k

Why does an increase in V cause k to decrease? Why does an increase in CL cause k to increase?

In this section, we can learn how clearance (CL) and volume of distribution (V) affect Eliminate Rate Constant (K).

This part includes a brain exercise and practical questions about a patient suffering from renal failure. If you are not quite sure with this idea, please feel free to leave your questions below.


Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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