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Which factor(s) impacts the loading dose ?

Which factor(s) impacts the loading dose? Volume, half-life, or clearance?

Continuing from the previous video, Prof. Brown specifies how a loading dose relates to the volume of distribution (V).

He shows the relationship between elimination and accumulation during a drug infusion, which is important for this lesson.

Can you tell which factor(s) impacts the loading dose for a patient? Is it the volume of distribution (V), clearance (CL), k, or half-life? This concept is explained further in two brain exercises in this video.

What do you think of the relationship between elimination and accumulation during a drug infusion? Please share your thoughts below.

Educator:

Prof. Daniel L. Brown

This article is from the free online

Clinical Pharmacokinetics: Dosing and Monitoring

Created by
FutureLearn - Learning For Life

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