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The concept of an accumulation factor

The concept of an accumulation factor

We can regard % lost as an “Accumulation Factor”.

With dose, volume (V), elimination rate constant (k), C times zero (C0), and tau, we can calculate e to the minus KT. Next, we can easily know that one minus e to the minus KT, which is the Accumulation Factor. Then we can obtain Cmax,ss and Cmin,ss .

Besides, Prof. Brown gives a clear illustration of drug accumulation and examples of the first-order linearity.

What is bioavailability? And how do we apply it? Please leave your answer below.


Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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