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How to change dose or dosing interval in response to a change in volume, clearance , or k ?

How to change dose or dosing interval in response to a change in volume, clearance, or k?

Finishing a brain exercise for measuring a drug serum concentration (C), Prof. Brown starts to explain how to adapt the dose and dosing interval (tau).

The changes in volume (V) and clearance (CL) are out of our control, but we can change the dose and dosing interval (tau) to optimize the drug use.

There are four examples in this video, and the baseline one is given 500mg q12h. In these cases, we can understand how the dose and dosing interval (tau) affect Cmax, Cmin, and AUC.

This part is important, so please leave any question you may have!

Educator:

Prof. Daniel L. Brown

This article is from the free online

Clinical Pharmacokinetics: Dosing and Monitoring

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FutureLearn - Learning For Life

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