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What happens when volume increases?

What happens when volume increases? Will AUC change?

Prof. Brown explains the situation for an increase in volume (V).

If volume (V) doubles, we should double dosing interval (tau) and the dose at the same time, or simply double the dose? Both conditions are discussed in this section.

Finally, we need to know the reason why AUC keeps the same even if volume (V) changes. You can try to write down the relationship between AUC and k to figure out the answer.

Feel free to share any question you may have.


Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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