Skip main navigation

New offer! Get 30% off one whole year of Unlimited learning. Subscribe for just £249.99 £174.99. New subscribers only. T&Cs apply

Find out more

Antisense Technology


The principle behind antisense technology is that an antisense nucleic acid sequence base pairs with its complementary sense RNA strand and prevents it from being translated into a protein. The oligonucleotide must be nontoxic and sufficiently specific so as not to interfere with other cellular functions. Over the years, chemical modifications of antisense oligonucleotides have not only enhanced the specificity and efficacy but also reduced the side effects.

The basic idea of antisense technology: A synthetic oligonucleotide RNA or DNA molecule complementary to a mRNA is introduced into a cell, The oligonucleotide specifically binds to the target mRNA through the exquisite specificity of complementary based pairing The binding forms an RNA dimmer in the cytoplasm and halts protein synthesis

This article is from the free online

Pharmacotherapy: Understanding Biotechnology Products

Created by
FutureLearn - Learning For Life

Reach your personal and professional goals

Unlock access to hundreds of expert online courses and degrees from top universities and educators to gain accredited qualifications and professional CV-building certificates.

Join over 18 million learners to launch, switch or build upon your career, all at your own pace, across a wide range of topic areas.

Start Learning now