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Complex Response Model

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By definition, a complex response model implies the involvement of complex physiologic and regulatory pathways. Logically, the model could be a combination of 2 or more existing models, with biofeedback mechanism, physiological tolerance or other attributes. These five models form a Model-Based Drug Development paradigm which has been used as a strategy for improving pharmaceutical R&D productivity.

The last model to be discussed in this section is the complex response model By definition, the model implies the involvement of complex physiologic and regulatory pathways. The physiologic pathway could include stimulation or inhibition of physiologic process, for example, the suppression and stimulation effect of LH-RH antagonist Regulatory pathway could involve molecular response mediators such as hormones or cytokines. In addition, the model could be a combination of 2 or more existing models, with biofeedback or physiological tolerance. The implications of PK/PD modeling is recaptured in a brief review.

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Pharmacotherapy: Understanding Biotechnology Products

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