Summary: Considerations in Clinical Relevance

Prof. Mary Ferrill demonstrates important principles and concludes this week.

Again, we are reminded to use the FACTS to evaluate the studies. What we are supposed to do is to formulate the null hypothesis, assess the NI margin, compare the ITT and PP results, translate the CI results graphically, and finally summarize the clinical relevance of the results.

Also, we need to consider three aspects of clinical relevance: Safety, Efficacy, and Cost/CPG/Convenience.

In conclusion, when we face a clinical trial, we have to question everything, especially on non-inferiority trials. Then, we need to investigate and analyze as much as possible, and finally share our findings with others.

This is the end of this week, if you have any questions or thoughts, please share them below.