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The expected outcome

This article deals with the expected outcomes of the different kind of treatments for brain tumours.
The clinicians discussing brain scans

We just heard the surgical team consult the patient and explain the procedure and its struggles. One might wonder if such a procedure is necessary, as it seems highly invasive and extremely stressful for the patient. Of course, the clinical team would never decide for an awake brain surgery, if it was not overall beneficial and the best option. Here are the numbers of why current medicine has arrived at such a decision.

HGG treatment and outcome HGG treatment and outcome

For High-Grade Gliomas (HGGs) , the average life expectancy is 1 year, if no treatment is done at all (A). If an extensive resection can be performed, the average expectancy is at around 2 years(B). If resection is combined with radio therapy, the average life expectancy is increased to up to 3 years(C). The best results of over 3 years seem to be achieved with a resection of more than 95%, and combined radio therapy and chemotherapy(D).

LGG removal and outcome LGG removal and outcome

The picture looks quite different for Low-Grade Gliomas (LGGs). When comparing gross total resection (which means around 95% of the infiltrated tissue is resected (C)) to partial resection of around around 80% (B) and around 60% (A), (where there is some tumour tissue left behind) the life expectancy is higher for the gross total resection with up to 14 years of survival(C).

And this is not all we have to consider. A patient may have a lifespan prolonged for up to 14 years, but a gross total resection may result in a much lower quality of life after surgery for instance: what if the patient lost the ability to use language for the remaining years due to a total resection? This is where language testing during awake surgery makes a difference.

Here is what we can learn when we compare deficits in language performance after classical surgery (no awake patient, hence, no language testing) vs. after awake brain surgery in a review of De Witt Hamer et al. 2012: the immediate effect for classic surgery is minor deficits in 14% of the cases and severe deficits in 11% of the cases. For awake surgery they report minor deficits in 47% of the cases and severe deficits in 36% of the cases. Immediately after surgery, it looks like the classic surgery delivers better results.

However, the numbers change drastically for the long term deficits. A couple of months after a classical surgery, there are minor deficits found in 9% of the cases and severe deficits in 8% of the cases. With an awake procedure, in only 6% of the cases a mild deficit appeared and in only 3% a severe deficit. From this it is concluded, that for LGG removal in language areas, the awake procedure is the best procedure.

Mind you, these numbers concern LGG resections. As mentioned earlier, HGG are often not operated on with an awake surgery. Impairment of language or other cognitive function is inevitable due to the gross resection needed. Even if operated on awake, the specific patient’s language skills may not recover in time for his remaining life expectancy after such an extensive resection. It, however, depends on the single case of the patient. Due to medical advances, more and more HGG are operated on succesfully, but not all centers are doing so yet.

© University of Groningen
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Language Testing During Awake Brain Surgery

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