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Metabolic syndrome and dementia


Prof Lin will discuss the relationship between metabolic syndrome, specifically type 2 diabetes, and dementia. Type 2 diabetes is a disease characterized by insulin resistance which results in hyperglycemia and accumulation of Ab amyloid. It reduces the utilization of glucose in the brain, leading to fatigue and potentially causing Alzheimer’s disease, which is sometimes referred to as “type 3 diabetes”.

The video explains how obesity, insulin resistance, and nonalcoholic steatohepatitis can lead to the accumulation of toxic substances such as ceramides and toxic lipids, which cause damage to neuron cells and result in Mild Cognitive Impairment. This can eventually lead to dementia.

Review Questions:

  • What is type 2 diabetes and how does it affect the brain?
  • What is the relationship between obesity and the development of Alzheimer’s disease?
  • How does the accumulation of toxic substances contribute to the development of Mild Cognitive Impairment and dementia?
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Nutrition and Age-Related Chronic Diseases

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