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GFR Estimation : Cockroft-Gault Equation

GFR Estimation : Cockroft-Gault Equation

Continuing from the previous step, Prof. Lee illustrates Cockroft-Gault Equation this time.

To begin with, we have to know that direct measurement of GFR by endogenous creatinine is most accurate but inconvenient, and the use of radio-labeled agent is undesirable. Consequently, we would use Ccr to estimate GFR.

There are four formulas available, including Cockroft-Gault, MDRD, Jelliffe Method, and Schwart. Prof. Lee clarifies Cockroft-Gault first since it is the most common one.

While using this formula, it is necessary for us to know that correction factor is 0.85 for female, assumed 15% lower in muscle mass.

Ultimately, we need to know when to use ideal or adjusted body weight, and we must understand how to calculate ideal body weight and adjusted body weight.

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Pharmacokinetics: Drug Dosing in Renal Disease

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