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TDM : Examples : Phenytoin & Digoxin

TDM : Examples : Phenytoin & Digoxin

In this step, Prof. Lee gives two examples of TDM and summarizes this week.

For Phenytoin, we must know that it has concentration-related toxicity. When the serum concentration is over 20 mg/L, the patient may experience nystagmus and ataxia. As a result, the clinical common range for Phenytoin is between 10 and 20 mg/L.

Besides, we need to know the monitoring time to measure the trough correctly.

For digoxin, there are many reasons to monitor its serum level, including compliance, suspected toxicity, and drug interactions. When monitoring the digoxin level, please observe the clinical response from the patient as well.

Please have some time to reflect upon the dosing regimen in renal failure and the therapeutic drug monitoring. If you have any thoughts or question about this week, please leave them below.

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Pharmacokinetics: Drug Dosing in Renal Disease

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