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Single and Multiple Intermittent Infusion Equations

Single and Multiple Intermittent Infusion Equations

Prof. Lee introduces single and multiple intermittent infusion equations in this step. He starts with single intermittent infusion.

To begin with, he illustrates how to calculate the concentration at any time after constant rate IV infusion. Following that, he also demonstrates how to derive the peak concentration after the first infusion, and get the trough concentration after the first dose.

Besides, we can know the concept of steady-state from the diagram in this video.

For multiple intermittent infusion equations, there are five key parameters, including peak concentration at steady-state, trough concentration at steady-state, volume of distribution, dosing interval, and recommended dose.

Therefore, knowing the elimination rate constant, the volume of distribution, the dosing infusion time, and how to perform the intermittent infusion, we will be able to derive the recommend dose.

Ultimately, the infusion rate is equal to the dose divide by cap T, the infusion time.

If you have any questions or thoughts, please share them below.

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Pharmacokinetics: Drug Dosing in Renal Disease

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