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General questions 2-4 : Drug regimen and protein binding

General questions 2-4 : Drug regimen and protein binding

Continuing from the previous step, Prof. Lee illustrates 3 general questions this time.

For the second general question, it is obvious that we should decrease the dosage since the patient’s estimated GFR is only 30 mL/min.

For the third one, the key is that the volume of distribution (V) remains unchanged.

Do you still remember how to calculate the loading dose? It is the product of V and steady-state concentration. Therefore, due to the unchanged V, it is clear that loading dose should stay the same as well. When a patient’s renal function is damaged severely, we should prolong the dosing interval for sure.

For the fourth question, we should keep in mind that the protein binding for the drug is most likely to affect a drug’s volume of distribution.

If you have any questions or thoughts, please do not hesitate to leave them below.

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Pharmacokinetics: Drug Dosing in Renal Disease

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