General questions 8-9 : Gentamycin and initial dose estimation

Continuing from the previous step, Prof. Lee illustrates the eighth and the ninth general question this time.

For the eighth question, there is a specific equation for aminoglycosides: 0.00293 times creatinine clearance, then plus 0.014, we will get the k.

For the ninth question, it is straightforward that we need to know the fraction of drug excreted unchanged and renal function of the patient as a fraction of normal.

These can help us estimate initial dose for patients in renal failure. On the other hand, the volume of distribution is irrespective of this question.