Skip main navigation

Evaluation of renal disease progression: Markers

Evaluation of renal disease progression: Markers
14.5
And there is a very famous calculation formula for calculating serum creatinine to creatinine clearance and that’s called cockcroft and gault method And these in this method I think a lot of people actually learn it previously and one thing I want to remind is about using lean body weight that means using the muscle to calculate calculator creatinine because you know for the patient with overweight they may have a lot of fat but that couldn’t produce creatinine So using lean body weight is a very important point by calculating this as creatinine into creatinine clearance and also need to remember the factor for female and lean body weight formula could be different in different countries and hereby thus the formula from textbook but in your own country for example, a lots of Asian country, the calculation and the the cockcroft for lean body weight could be very different.
95
So you could actually check your local reference for lean body weight. And BUN, as a very important matter to generally to look at the function for filtration and urea as final product of protein catabolism and it can actually help us to know the filtration and the absorption for kidney and the normal level is around 10 to 50 mg/dL but however when a patient has decreased kidney function the patient may have some level above 15 or 18 and …but because this is a very specific matter. So you can actually differentiate if your patient has other issues or other problems related to this increase BUN function.
160.1
So we need to check implication if patient has very high protein diet; or the patient has febrile illness infection with high catabolism. So they may have a lot of protein breakdown or using some special medication for example steroids, tetracycline and or the patient has a GI bleeding or hyperthyroidism. So after removing these factors, you may actually see the BUN level back to normal and less indicating that the patient did not have a CKD. And UA, urine analysis And urine analysis is the same.
209
It actually could tell you a lot of different diseases not only CKD and we normally check color and those chemical property for urine and also check out pH value and concentrating value as the important because there’s an indication about provocations fruit intake and those are the patient’s kidney function. so the gravity is important and osmolality of urine is important and for protein content it actually tells you lots of a disease progression and also probably some issue about infection and also finally that could be also indicator about CKD. And so there will be other factor we want to check including RBC why Y bar cells appearance in urine or some casts and that’s also important.
280.5
And one very important factor is about sodium excretion. And usually there will have a big very important calculation about differentiation diseases.
In this step, Prof. Chen introduces several markers to evaluate the progression of CKD and the kidney function of patients.
To begin with, she emphasizes the importance of lean body weight in C-G Method. Therefore, please check your local reference for lean body weight.
Secondly, the normal level of BUN is around 10 to 15 mg/dL. When a patient’s level is above 18, we should notice if there is any risk factor. After removing those factors, you may find the BUN level back to normal.
Finally, the urinalysis is important as well. We need to check the physical and chemical properties, pH value, protein content, and sodium excretion.
If you have any questions or thoughts, please leave them below.
This article is from the free online

Pharmacokinetics: Drug Dosing in Renal Disease

Created by
FutureLearn - Learning For Life

Our purpose is to transform access to education.

We offer a diverse selection of courses from leading universities and cultural institutions from around the world. These are delivered one step at a time, and are accessible on mobile, tablet and desktop, so you can fit learning around your life.

We believe learning should be an enjoyable, social experience, so our courses offer the opportunity to discuss what you’re learning with others as you go, helping you make fresh discoveries and form new ideas.
You can unlock new opportunities with unlimited access to hundreds of online short courses for a year by subscribing to our Unlimited package. Build your knowledge with top universities and organisations.

Learn more about how FutureLearn is transforming access to education